6-Hydroxydopamine lesioning differentially affects α-synuclein mRNA expression in the nucleus accumbens, striatum and substantia nigra of adult rats
| Autor: | Peter Jenner, Bai-Yun Zeng, A. Owen, Carla Cannizzaro, Banu C. Tel, B. Dass, Stephen E. Rose |
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| Přispěvatelé: | ZENG, BY, DASS, B, OWEN, A, ROSE, S, CANNIZZARO, C, TEL, BC, JENNER, P |
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Tyrosine 3-Monooxygenase Dopamine animal diseases Dopamine Agents Synucleins Nerve Tissue Proteins Substantia nigra Striatum Nucleus accumbens Biology Drug Administration Schedule Nucleus Accumbens chemistry.chemical_compound Internal medicine Basal ganglia medicine Animals Tyrosine hydroxylase mRNA RNA Messenger Rats Wistar Oxidopamine Neurons Hydroxydopamine Tyrosine hydroxylase General Neuroscience Parkinson Disease α-Synuclein mRNA Rats nervous system diseases Neostriatum Substantia Nigra Endocrinology nervous system chemistry Sympatholytics alpha-Synuclein Settore BIO/14 - Farmacologia 6-Hydroxydopamine medicine.drug |
| Zdroj: | Neuroscience Letters. 322:33-36 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/s0304-3940(02)00083-6 |
| Popis: | The effect of a unilateral 6-hydroxydopamine (6-OHDA) lesion and/or repeated administration of levodopa (L-DOPA) to normal and 6-OHDA-lesioned rats on alpha-synuclein mRNA expression was investigated by in situ hybridization histochemistry. A 6-OHDA lesion of the nigro-striatal pathway alone, confirmed by the loss of nigral tyrosine hydroxylase mRNA expression, markedly decreased alpha-synuclein mRNA in the lesioned substantia nigra (SN). In contrast, the levels of alpha-synuclein mRNA in the denervated striatum and nucleus accumbens were not altered. Chronic administration of L-DOPA to normal or 6-OHDA-lesioned rats had no effect on alpha-synuclein mRNA expression in the SN, striatum or nucleus accumbens. These data confirm that alpha-synuclein is localized in the nigro-striatal tract but that its gene expression is not regulated by dopamine. |
| Databáze: | OpenAIRE |
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