Generation and Cycloaddition of Polymer-Supported Azomethine Ylide via a 1,2-Silatropic Shift of α-Silylimines: Traceless Synthesis of Pyrrolidine Derivatives

Autor:	Hirofumi Okada, Tatsuo Akaki, Satoshi Minakata, Yoji Oderaotoshi, Mitsuo Komatsu
Rok vydání:	2002
Předmět:	chemistry.chemical_compound Chemistry Stereochemistry Organic Chemistry Azomethine ylide Physical and Theoretical Chemistry Biochemistry Combinatorial chemistry Cycloaddition Polymer supported Pyrrolidine
Zdroj:	Organic Letters. 4:3505-3508
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol026634n
Popis:	The 1,3-dipolar cycloaddition of polymer-supported azomethine ylides to dipolarophiles gave pyrrolidine derivatives in good yields. The azomethine ylides were generated from resin-bound alpha-silylimines via a 1,2-silatropic shift. The features of this method are not only a traceless synthesis but also a unique solid-phase route to pyrrolidines with extensive diversity. [reaction: see text]
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ca9c3a8fdf9cdce1f0e92a6f047440 https://doi.org/10.1021/ol026634n Zobrazit plný text záznamu