High level perinuclear antineutrophil cytoplasmic antibody (pANCA) in ulcerative colitis patients before colectomy predicts the development of chronic pouchitis after ileal pouch-anal anastomosis
| Autor: | Eric A. Vasiliauskas, N E Fleshner, J Gaiennie, Maria T. Abreu-Martin, Lori Y. Kam, S. R. Targan, Philip Fleshner |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Statistics as Topic Enzyme-Linked Immunosorbent Assay Pouchitis Anastomosis Gastroenterology Article Antibodies Antineutrophil Cytoplasmic Predictive Value of Tests Median follow-up Internal medicine Humans Medicine Prospective Studies Colitis Child Fluorescent Antibody Technique Indirect Aged Colectomy biology Panca business.industry Proctocolectomy Proctocolectomy Restorative Middle Aged biology.organism_classification medicine.disease Ulcerative colitis Surgery Acute Disease Chronic Disease Colitis Ulcerative Female business Biomarkers |
| Zdroj: | Gut. 49:671-677 |
| ISSN: | 0017-5749 |
| DOI: | 10.1136/gut.49.5.671 |
| Popis: | BACKGROUND—The reported cumulative risk of developing pouchitis in ulcerative colitis (UC) patients undergoing ileal pouch-anal anastomosis (IPAA) approaches 50% after 10 years. To date, no preoperative serological predictor of pouchitis has been found. AIMS—To assess whether preoperative perinuclear antineutrophil cytoplasmic antibody (pANCA) expression was associated with acute and/or chronic pouchitis after IPAA. METHODS—Patients were prospectively assessed for the development of clinically and endoscopically proved pouchitis. Serum obtained at the time of colectomy in 95 UC patients undergoing IPAA was analysed for pANCA by ELISA and indirect immunofluorescence. pANCA+ patients were stratified into high level (>100 ELISA units (EU)/ml) (n=9), moderate level (40-100 EU/ml) (n=32), and low level ( |
| Databáze: | OpenAIRE |
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