Association of Habitual Preoperative Dietary Fiber Intake With Complications After Colorectal Cancer Surgery
| Autor: | Henk K. van Halteren, Tess Huibregtse, Moniek van Zutphen, Melissa N.N. Arron, Fränzel J.B. Van Duijnhoven, Flip M. Kruyt, Johannes H. W. de Wilt, Renate M. Winkels, Ellen Kampman, Dirk Jan Bac, Evertine Wesselink, Dieuwertje E. Kok, Ewout A. Kouwenhoven |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Nutrition and Disease Colorectal cancer Prehabilitation 030230 surgery Lower risk Preoperative care 03 medical and health sciences Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] 0302 clinical medicine All institutes and research themes of the Radboud University Medical Center Interquartile range Internal medicine Voeding en Ziekte medicine Life Science VLAG Original Investigation business.industry Odds ratio medicine.disease 030220 oncology & carcinogenesis Surgery business Cohort study Abdominal surgery |
| Zdroj: | JAMA Surgery, 156, 9, pp. 827-835 JAMA Surg JAMA Surgery, 156, 827-835 JAMA Surgery 156 (2021) 9 JAMA Surgery, 156(9) |
| ISSN: | 2168-6254 |
| Popis: | Importance Postoperative complications are associated with increased morbidity and mortality among patients with colorectal cancer. As a modifiable factor associated with gut health, dietary fiber intake is of interest with regard to the risk of complications after surgery for colorectal cancer. Objective To examine the association between preoperative dietary fiber intake and risk of complications after surgery for colorectal cancer. Design, setting, and participants This cohort study used data from the Colorectal Longitudinal, Observational Study on Nutritional and Lifestyle Factors (COLON) study, which recruited adult patients with colorectal cancer at any stage at diagnosis from 11 hospitals in the Netherlands between August 2010 and December 2017. The present study included patients with stage I to IV colorectal cancer who underwent elective abdominal surgery. Data were analyzed between December 2019 and September 2020. Exposures Habitual dietary fiber intake was assessed at diagnosis using a 204-item food frequency questionnaire. Main outcomes and measures Any complications, surgical complications, and anastomotic leakage occurring during the 30 days after surgery for colorectal cancer. The association between fiber intake and risk of postoperative complications was assessed using logistic regression analyses. Additional analyses stratified by sex, tumor location, and fiber source were performed. Results Among the 1399 patients included in the analysis, the median age at inclusion was 66 years (interquartile range, 61-72 years) and 896 (64%) were men. Any complications occurred in 397 patients (28%), and surgical complications occurred in 235 patients (17%). Of 1237 patients with an anastomosis, 67 (5%) experienced anastomotic leakage. Higher dietary fiber intake (per 10 g per day) was associated with a lower risk of any complications (odds ratio [OR], 0.75; 95% CI, 0.62-0.92) and surgical complications (OR, 0.76; 95% CI, 0.60-0.97), whereas no association with anastomotic leakage was found (OR, 0.97; 95% CI, 0.66-1.43). Among women, higher dietary intake was associated with any complications (OR, 0.64; 95% CI, 0.44-0.94), whereas there was no association among men (OR, 0.79; 95% CI, 0.63-1.01). Fiber intake from vegetables (per 1 g per day) was inversely associated with any (OR, 0.90; 95% CI, 0.83-0.99) and surgical (OR, 0.87; 95% CI, 0.78-0.97) complications. Conclusions and relevance In this cohort study, higher habitual dietary fiber intake before surgery was associated with a lower risk of postoperative complications among patients with colorectal cancer. The findings suggest that improving preoperative dietary fiber intake may be considered in future prehabilitation programs for patients undergoing surgery for colorectal cancer. |
| Databáze: | OpenAIRE |
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