Microscopic colitis in Uppsala health region, a population-based prospective study 2005–2009
| Autor: | Anders Ekbom, Daniel Sjöberg, Tommy Holmström, Anders Rönnblom, Mari Thörn, Lars Holmquist, Anne-Lie Nielsen, Ulrika Thelander, Märit Larsson, Alkwin Wanders |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Diarrhea Male medicine.medical_specialty Adolescent Anti-Inflammatory Agents Gastroenterology Inflammatory bowel disease Young Adult Microscopic colitis Internal medicine Epidemiology medicine Humans Prospective Studies Registries Colitis Young adult Prospective cohort study Aged Aged 80 and over Sweden business.industry Incidence Incidence (epidemiology) Middle Aged Inflammatory Bowel Diseases Concomitant drug medicine.disease digestive system diseases Colitis Microscopic Celiac Disease Female business |
| Zdroj: | Scandinavian Journal of Gastroenterology. 48:825-830 |
| ISSN: | 1502-7708 0036-5521 2005-2006 |
| DOI: | 10.3109/00365521.2013.800993 |
| Popis: | The aim of this study is to report on the incidence of microscopic colitis (MC), any possible relation with inflammatory bowel disease (IBD), concomitant drug consumption, related diseases and the clinical course of the diseases.Both new cases of IBD and MC were registered at the same time in the same geographical area. The study started in the county of Uppsala 2005-2006, and other parts of the surrounding health region were included 2007-2009. Established morphological criteria were used, i.e. a layer of subepithelial collagen band ≥ 10 μm in collagenous colitis (CC) with concomitant inflammation and at least 20 lymphocytes per 100 epithelial cells in lymphocytic colitis (LC).The authors found 272 new cases of MC, 154 with CC and 118 with LC. The mean age-adjusted incidence was 7.0/1,000,000 for CC and 4.8/100,000 for LC. The clinical course was dominated by single episodes with diarrhea or intermittent symptoms, but 14% suffered from chronic diarrhea. In 10% of the cases, diagnosis was made in individuals without chronic watery diarrhea. Although not systematically tested, concomitant celiac disease was found in approximately 5% of the patients.The incidence of MC in Uppsala health region is similar to other studied areas. The majority of patients had a self-limiting or easily treated condition, but 14% need a more or less continuous medication. Ten percent of the patients demonstrate other symptoms than chronic watery diarrhea. The possibility of concomitant celiac disease should be considered in new cases of MC. |
| Databáze: | OpenAIRE |
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