Associations between symptoms of depression and anxiety and cortisol responses to and recovery from acute stress
| Autor: | Luke Hanlin, Xuejie Chen, Alexander Fiksdal, Myriam V. Thoma, Nicolas Rohleder, Danielle Gianferante, Yuliya I. Kuras |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty endocrine system Hypothalamo-Hypophyseal System Hydrocortisone Endocrinology Diabetes and Metabolism Pituitary-Adrenal System Disease Anxiety Hospital Anxiety and Depression Scale Article 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Trier social stress test Medicine Humans Saliva Biological Psychiatry Depression (differential diagnoses) Social stress Depressive Disorder Major Endocrine and Autonomic Systems business.industry Depression Middle Aged medicine.disease Anxiety Disorders Allostatic load 030227 psychiatry Psychiatry and Mental health Major depressive disorder Female medicine.symptom business 030217 neurology & neurosurgery Stress Psychological |
| Zdroj: | Psychoneuroendocrinology. 102 |
| ISSN: | 1873-3360 |
| Popis: | Background: Anxiety disorders and major depressive disorder (MDD) have been associated with increased and blunted HPA axis reactivity to social stress. However, research focusing on associations between HPA axis responses to stress and symptoms of anxiety and depression among individuals without a diagnosis remains an understudied area of research. Methods: One hundred forty-three adults (52% female) completed the Trier Social Stress Test (TSST). Symptoms of depression and anxiety were assessed prior to the TSST using the anxiety and depression subscales of the Hospital Anxiety and Depression Scale (HADS). HPA axis responses were assessed by measuring salivary cortisol at baseline and following the TSST. Reactivity to and recovery from stress were assessed using multilevel growth modeling controlling for age, BMI, and sex among the full sample and a subset of cortisol responders (n = 72). Results: Anxiety symptoms were positively associated with flatter recovery slopes among the full sample (t(122.3) = 2.082, p = .039). Among cortisol responders, depression symptoms were associated with steeper reactivity (t(63.32) = 2.53, p = .026) and recovery (t(58.75)=−2.20, p = .03). Anxiety symptoms were associated with marginally flatter reactivity (t(64.00)=−1.97, p = .053) and significantly flatter recovery (t(59.22) = 2.29, p = .025). Conclusion: Symptoms of anxiety and depression among individuals without a psychiatric diagnosis are associated with blunted and exaggerated cortisol responses to and recovery from stress. Such patterns could indicate increased risk for unhealthy HPA axis dysregulation, allostatic load, and disease. |
| Databáze: | OpenAIRE |
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