Hair Testing for Classic Drugs of Abuse to Monitor Cocaine Use Disorder in Patients Following Transcranial Magnetic Stimulation Protocol Treatment
| Autor: | Luis Javier Gomez Perez, Stefano Cardullo, Roberta Pacifici, Graziella Madeo, Diego Cuppone, Luigi Gallimberti, Maria Concetta Rotolo, Manuela Pellegrini |
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| Rok vydání: | 2021 |
| Předmět: |
hair testing
Drug medicine.medical_specialty Drugs of abuse THC QH301-705.5 media_common.quotation_subject medicine.medical_treatment cocaine Craving Biology Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine repetitive transcranial magnetic stimulation (rTMS) biomarker Biology (General) media_common Protocol (science) integumentary system General Immunology and Microbiology Addiction Hair analysis 030227 psychiatry Transcranial magnetic stimulation Biomarker (medicine) sense organs medicine.symptom General Agricultural and Biological Sciences 030217 neurology & neurosurgery |
| Zdroj: | Biology; Volume 10; Issue 5; Pages: 403 Biology, Vol 10, Iss 403, p 403 (2021) Biology |
| ISSN: | 2079-7737 |
| Popis: | Simple Summary Hair testing for classic drugs of abuse offers the possibility of longer detection times (for drug substances) when compared to urine analysis. Hair analysis is routinely used to detect drug abuse in forensic cases and clinical toxicology, whereas it is rarely used at addiction clinics to monitor the clinical efficacy of therapeutic interventions. Here, we explore for the first time whether hair analysis might represent a valid tool to track the clinical improvements in a population of patients with cocaine use disorder (CocUD) who underwent a repetitive transcranial magnetic stimulation (rTMS) treatment. Abstract In recent years, hair has become an alternative biological specimen for drug testing in the fields of forensic and clinical toxicology. The advantages of hair testing include larger detection windows (months/years), depending on the length of the hair shaft, compared to those of urine/blood (hours to 2–4 days for most drugs). Segmental hair analysis can disclose a month-to-month (considering 1 cm segment cuts) information of drug exposure (single or repeated) and potentially identify patterns of drug use/administration. Repetitive transcranial magnetic stimulation (rTMS) was recently proposed as a valid tool for therapeutic purposes in addictions, including cocaine use disorder (CocUD). Here, we proposed hair testing analyses of classic drugs of abuse in a clinical setting to monitor the clinical changes in treatment-seeker CocUD patients undergoing protocol treatments with rTMS stimulating the left dorsolateral prefrontal cortex (l-DLPFC). We collected hair samples from nine CocUD patients at different stages from the beginning of treatments. Hair sample analyses revealed significant changes in the patterns of cocaine use, according to the negativity of urine screening tests and the clinical reductions of craving. These data, albeit preliminary, suggest that hair testing analysis of classic drugs of abuse could be extended to clinical settings to monitor the clinical efficacy of innovative therapeutic interventions, such as rTMS. |
| Databáze: | OpenAIRE |
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