Perfusion scintigraphy in the assessment of autologous cell therapy in diabetic patients with critical limb ischemia
| Autor: | Marie Buncová, Veronika Wosková, Andrea Nemcova, Robert Bém, Alexandra Jirkovská, Anna Pyšná, Michal Dubsky, Vladimíra Fejfarová |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Technetium Tc 99m Sestamibi medicine.medical_specialty Autologous cell Physiology Perfusion Imaging Cell- and Tissue-Based Therapy 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Scintigraphy Transplantation Autologous Calf muscles Cell therapy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Humans TCPO Aged Leg medicine.diagnostic_test business.industry General Medicine Critical limb ischemia Middle Aged Diabetic Foot body regions chemistry Diabetes Mellitus Type 2 Cardiology Female medicine.symptom Transcutaneous oxygen business Perfusion |
| Zdroj: | Physiological research. 67(4) |
| ISSN: | 1802-9973 |
| Popis: | Perfusion scintigraphy with technetium-99-methoxy-isobutyl-isonitrile (99mTc-MIBI) is often used for assessing myocardial function but the number of studies concerning lower limb perfusion is limited. The aim of our study was to assess whether 99mTc-MIBI was an eligible method for evaluation of the effect of cell therapy on critical limb ischemia (CLI) in diabetic patients. 99mTc-MIBI of calf muscles was performed before and 3 months after autologous cell therapy (ACT) in 24 diabetic patients with CLI. Scintigraphic parameters such as rest count and exercising count after a stress test were defined. These parameters and their ratios were compared between treated and untreated (control) limbs and with changes in transcutaneous oxygen pressure (TcPO2) that served as a reference method. The effect of ACT was confirmed by a significant increase in TcPO2 values (p˂0.001) at 3 months after ACT. We did not observe any significant changes of scintigraphic parameters both at rest and after stress 3 months after ACT, there were no differences between treated and control limbs and no association with TcPO2 changes. Results of our study showed no significant contribution of 99mTc-MIBI of calf muscles to the assessment of ACT in diabetic patients with CLI over a 3-month follow-up period. |
| Databáze: | OpenAIRE |
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