Antioxidant Activity Derived from Marine Green-Lipped Mussel Perna canaliculus Extracts in Mice

Autor:	Nuha A Anajirih, Abdullah F Aldairi, Mohammad A Albanghali, Yasser M Kofiah, Haitham A Bukhary, Ahmad Al-Ghamdi, Mamdouh Allahyani, Abdulraheem S. A. Almalki, Sulaiman A Anagreyyah, Ahmed H. Qasem, Asma A. Alsubaihi, Reema A. Alyamani, Ayman Al-Hazmi
Rok vydání:	2021
Předmět:	Antioxidant Article Subject medicine.medical_treatment education medicine.disease_cause behavioral disciplines and activities General Biochemistry Genetics and Molecular Biology Lipid peroxidation chemistry.chemical_compound medicine Food science Perna canaliculus chemistry.chemical_classification General Immunology and Microbiology biology Chemistry Toxin General Medicine Glutathione Carbohydrate biology.organism_classification Enzyme Catalase biology.protein Medicine psychological phenomena and processes
Zdroj:	BioMed Research International, Vol 2021 (2021)
ISSN:	2314-6141 2314-6133
DOI:	10.1155/2021/1622270
Popis:	This study investigates the antioxidant activities of lipid, protein, and carbohydrate extracts from the marine mollusk Perna canaliculus. Lipids were extracted using acetone, which was followed by protein extraction using the broad-spectrum enzyme Alcalase and then carbohydrate extraction using cetylpyridinium chloride. Eighty white BALB/c mice were divided into eight groups according to the administered extracts. Groups 1 and 5 were the control and toxin control groups, respectively. Groups 2, 3, and 4 were administered lipid, protein, and carbohydrate extracts, respectively. The other groups were administered P. canaliculus extracts as well as gentamicin and acetaminophen, known as ethanolic extracts, derived from Nerium oleander to induce oxidation stress. All groups showed significant improvements in body weight ( p < 0.05 ). The lipid extract group showed a significant decrease in low-density lipoprotein cholesterol ( p < 0.05 ) and a significant increase in high-density lipoprotein cholesterol ( p < 0.05 ). After the toxin injection, all groups treated with P. canaliculus extracts showed increased antioxidant effects on hepatocytes ( p < 0.05 ). The lipid extracts induced antioxidant effects to protect the kidney by increasing lipid peroxidation ( p < 0.05 ) and catalase activities ( p < 0.05 ). Also, protein extracts showed antioxidant effects by increasing glutathione and catalase levels significantly ( p < 0.005 ). In conclusion, P. canaliculus extracts, especially lipids and proteins, have potent antioxidant activities that protect vital organs from oxidation stress.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c47d2f1cb13e0b39452bef1e991322 https://doi.org/10.1155/2021/1622270 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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