A Polyunsaturated Fatty Acid Diet Lowers Blood Pressure and Improves Antioxidant Status in Spontaneously Hypertensive Rats
| Autor: | Josiane Prost, Jacques Belleville, Emmanuelle D. Prost, Jean-Marie R. Frenoux |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Lipid Peroxides
medicine.medical_specialty Time Factors Antioxidant Docosahexaenoic Acids Platelet Aggregation Thiobarbituric acid medicine.medical_treatment Medicine (miscellaneous) Blood Pressure Biology Rats Inbred WKY Antioxidants Lipid peroxidation chemistry.chemical_compound Rats Inbred SHR Internal medicine medicine Animals gamma-Linolenic Acid gamma-Linolenic acid chemistry.chemical_classification Nutrition and Dietetics Dietary Fats Lipids Eicosapentaenoic acid Rats Endocrinology Eicosapentaenoic Acid chemistry Docosahexaenoic acid Hypertension Fatty Acids Unsaturated lipids (amino acids peptides and proteins) Lipoprotein Polyunsaturated fatty acid |
| Zdroj: | The Journal of Nutrition. 131:39-45 |
| ISSN: | 0022-3166 |
| Popis: | gamma-Linolenic acid [GLA, 18:3(n-6)], eicosapentaenoic acid [EPA, 20:5(n-3)] and docosahexaenoic acid [DHA, 22:6(n-3)] have been reported to prevent cardiovascular diseases. However, they are highly unsaturated and therefore more sensitive to oxidation damage. We investigated the effects of a diet rich in these polyunsaturated fatty acids (PUFA) on blood pressure, plasma and lipoprotein lipid concentrations, total antioxidant status, lipid peroxidation and platelet function in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY). Five-week-old SHR and WKY rats were fed for 10 wk either a diet containing Isio 4 oil or a diet rich in GLA, EPA and DHA (5.65, 6.39 and 4.94 g/kg dry diet, respectively). The total antioxidant status was assayed by monitoring the rate of free radical-induced hemolysis. VLDL-LDL sensitivity to copper-induced lipid peroxidation was determined as the production of thiobarbituric acid reactive substances. After dietary PUFA supplementation, a significant decrease in blood pressure of SHR rats (-20 mm Hg) was observed and the total antioxidant status was enhanced. VLDL-LDL resistance to copper-induced peroxidation was increased in both strains. The PUFA supplementation did not change platelet maximum aggregation in SHR rats, but it decreased the aggregation speed. In hypertensive rats, GLA + EPA + DHA supplementation lowers blood pressure, enhances total anti-oxidant status and resistance to lipid peroxidation, diminishes platelet aggregation speed and lowers plasma lipid concentrations. Thus, it enhances protection against cardiovascular diseases. Therefore, nutritional recommendations for cardiovascular disease prevention should take into account the pharmacologic properties of GLA, EPA and DHA. |
| Databáze: | OpenAIRE |
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