Cerebral oxygenation associated with INSURE versus LISA procedures in surfactant‐deficient newborn piglet RDS model

Autor: Miguel Angel Gomez-Solaetxe, Fabrizio Salomone, Victoria E. Mielgo, Carmen Rey-Santano, B Loureiro, Elena Gastiasoro
Rok vydání: 2019
Předmět:
Pulmonary and Respiratory Medicine
Carotid Artery
Common
Swine
surfactant
Hemodynamics
Lung injury
Neonatal Lung Disease
Bronchoalveolar Lavage
Random Allocation
03 medical and health sciences
0302 clinical medicine
030225 pediatrics
Heart rate
Intubation
Intratracheal
cerebral oxygenation
INSURE
Animals
Medicine
Lung
Original Article: Neonatal Lung Disease
Respiratory Distress Syndrome
Newborn
Spectroscopy
Near-Infrared
LISAcath®
Continuous Positive Airway Pressure
Respiratory distress
Pulmonary Gas Exchange
business.industry
Brain
Pulmonary Surfactants
Lung Injury
Blood flow
respiratory distress syndrome
Oxygen
Blood pressure
medicine.anatomical_structure
NIRS
Animals
Newborn
030228 respiratory system
Cerebrovascular Circulation
Anesthesia
Pediatrics
Perinatology and Child Health
Airway Extubation
Breathing
ORIGINAL ARTICLES
business
Zdroj: Pediatric Pulmonology
ISSN: 1099-0496
8755-6863
DOI: 10.1002/ppul.24277
Popis: Background Nasal continuous‐positive airway pressure (nCPAP) with the INSURE (INtubation‐SURfactant‐Extubation) or LISA (Less‐Invasive Surfactant Administration) procedures are increasingly being chosen as the initial treatment for neonates with surfactant deficiency. Our objective was to compare the effects on cerebral oxygenation of different methods for surfactant administration: INSURE and LISA, using a nasogastric tube (NT) or a LISAcath® catheter, in spontaneously breathing SF‐deficient newborn piglets. Methods Eighteen newborn piglets with SF‐deficient lung injury produced by repetitive bronchoalveolar lavages were randomly assigned to INSURE, LISA‐NT, or LISAcath® groups. We assessed pulmonary (gas exchange, lung mechanics, lung histology) and hemodynamic (mean arterial blood pressure, heart rate) changes, cerebral oxygenation (cTOI) and cerebral fractional tissue extraction (cFTOE), with near‐infrared spectroscopy, carotid blood flow and brain histology. Results SF‐deficient piglets developed respiratory distress (FiO2 = 1, pH 70 mmHg, PaO2
Databáze: OpenAIRE
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