Resistance to noise-induced gap detection impairment in FVB mice is correlated with reduced neuroinflammatory response and parvalbumin-positive neuron loss
| Autor: | Alexander K. Zinsmaier, Weihua Wang, Nadia N. Hossainy, Li Zhang, Shaowen Bao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Noise induced Science Mice Inbred Strains Article 03 medical and health sciences Mice 0302 clinical medicine Inbred strain Species Specificity Internal medicine medicine Animals Neuroinflammation Neurons Multidisciplinary biology Tumor Necrosis Factor-alpha Auditory Perceptual Disorders Gap detection Cortex (botany) Mice Inbred C57BL Disease Models Animal 030104 developmental biology Endocrinology medicine.anatomical_structure Parvalbumins biology.protein Cortex Medicine Tumor necrosis factor alpha Sensory processing Neuron Noise 030217 neurology & neurosurgery Parvalbumin |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) |
| ISSN: | 2045-2322 |
| Popis: | Exposure to loud noises results in neuroinflammatory responses in the central auditory pathway. Noise-induced neuroinflammation is implicated in auditory processing deficits such as impairment in gap detection. In this study, we examined whether strain differences between the FVB and C57BL/6 mice in noise-induced impairment in gap detection are correlated with strain differences in neuroinflammatory responses. We found that noise induced more robust TNF-α expression in C57BL/6 than in FVB mice. Noise-induced microglial deramification was observed in C57BL/6 mice, but not in FVB mice. Furthermore, noise exposure resulted in a reduction in parvalbumin-positive (PV+) neuron density in the C57BL/6 mice, but not in FVB mice. These results suggest that neuroinflammatory responses and loss of PV+ neurons may contribute to strain differences in noise-induced impairment in gap detection. |
| Databáze: | OpenAIRE |
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