Correlation between serum cytokeratin-18 and the progression or regression of non-alcoholic fatty liver disease
| Autor: | Gotaro Yamada, Jun Nakamura, Noriyo Urata, Mitsuhiko Suehiro, Miwa Kawanaka, Takahito Oka, Ken Nishino, Daisuke Goto, Hirofumi Kawamoto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Time Factors CK-18 Biopsy Specialties of internal medicine Enzyme-Linked Immunosorbent Assay Gastroenterology Cytokeratin Young Adult Non-alcoholic Fatty Liver Disease Predictive Value of Tests Risk Factors Internal medicine medicine Humans Young adult Non-alcoholic steatohepatitis Aged Hepatology medicine.diagnostic_test Receiver operating characteristic Keratin-18 business.industry Fatty liver Remission Induction General Medicine Middle Aged medicine.disease digestive system diseases Up-Regulation Treatment Outcome ROC Curve RC581-951 Liver biopsy Predictive value of tests Area Under Curve Disease Progression Female Steatohepatitis business Fibrosis NAFLD activity score (NAS) Biomarkers |
| Zdroj: | Annals of Hepatology, Vol 14, Iss 6, Pp 837-844 (2015) |
| ISSN: | 1665-2681 |
| Popis: | Background. Diagnosis of non-alcoholic fatty liver disease (NAFLD) is limited by the need for liver biopsies. Serum cytokeratin 18 (CK-18) levels have been investigated as potential biomarkers for the presence of NAFLD and non-alcoholic steatohepatitis (NASH). Herein, we assessed the correlation between CK-18 levels and NAFLD progression. Material and methods. Serum CK-18 levels were estimated using the M30 antibody enzyme-linked immunosorbent assay in 147 patients diagnosed with NAFLD. In 72 patients, disease progression was evaluated by repeated liver biopsy, which was conducted after 4.3 ± 2.6 years. The relationship between the CK-18 levels and liver histological findings was assessed. Results. The CK-18 levels were useful for identifying NAFLD patients with NAFLD activity scores (NAS) ≥ 5 (NAS ≥ 5 vs. ≤ 4: 675.1 U/L vs. 348.7 U/L; p < 0.0001). A cut-off value of 375 U/L was calculated using the receiver operating characteristic curve approach, with a specificity and sensitivity of 81.5 and 65%, respectively, for the diagnosis of NASH. Among the 72 patients who underwent repeated liver biopsy, 11 patients with a progressed NAS also had significantly increased serum CK-18 levels (p < 0.01); in 30 patients with an improved NAS, there was a significant improvement in the mean CK-18 levels (p < 0.0001). The 31 patients with static NAS had static CK-18 levels. Conclusions. In conclusion, serum CK-18 levels can predict NAS ≥ 5 in NAFLD patients. In NAFLD patients, serum CK-18 levels reflect NAS values and correlate with histological changes, and they appear to be useful indicators of progression and improvement. |
| Databáze: | OpenAIRE |
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