Relationship between H.Pylori infection and clinicopathological features and prognosis of gastric cancer
| Autor: | Zhiwei Zhou, Da Zhi Xu, Hai Bo Qiu, Rajiv Prasad Keshari, You Qin Zhan, L. Zhang, Guo Qiang Wang, Wei Li, Wei Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Polymerase Chain Reaction Gastroenterology lcsh:RC254-282 Helicobacter Infections Stomach Neoplasms Surgical oncology Internal medicine Genetics Carcinoma Humans Medicine Stomach cancer Survival rate Aged Neoplasm Staging Retrospective Studies Mucous Membrane Helicobacter pylori biology business.industry Proportional hazards model Cancer Retrospective cohort study Middle Aged bacterial infections and mycoses Prognosis medicine.disease biology.organism_classification lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Survival Rate Oncology DNA Viral Female Neoplasm Recurrence Local business Carcinoma Signet Ring Cell Follow-Up Studies Research Article |
| Zdroj: | BMC Cancer, Vol 10, Iss 1, p 374 (2010) BMC Cancer |
| ISSN: | 1471-2407 |
| Popis: | Background Aimed to assess the relationship between H.Pylori and the clinicopathological features and prognosis of gastric cancer by quantitative detection of H.Pylori. Methods 157 patients were enrolled, all patients had a record of clinicopathological parameters. Specimens including the tumor and non-neoplastic were detected for H.Pylori by Real-Time PCR and analyzed clinical data retrospectively. Variables independently affecting prognosis were investigated by means of multivariate analysis using the Cox proportional hazards model. Results H.Pylori infection was greater in non-neoplastic tissue than the tumor tissue (p < 0.05), H.Pylori infection and its copies were related to the tumor site and N staging (p < 0.05). Overall survival (OS) in all 157 patients has no correlation with the H.Pylori infection status (p = 0.715). As to the patients who underwent a curative surgery, relapse-free survival (RFS) has no correlation with the H.Pylori infection status (p = 0.639). Among the H.Pylori positive patients, OS and RFS of those with higher copies were longer than in patients with low copies, but there was no significant statistical difference. Conclusions H.Pylori infection status and its copies were related to N staging. The OS and RFS in patients with positive H.Pylori status has no significant difference from the patients with negative H.Pylori status. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink