A randomised study on the clinical progress of high-risk elective major gastrointestinal surgery patients treated with olive oil-based parenteral nutrition with or without a fish oil supplement
| Autor: | Josep Maria Ramon-Torrell, Leandre Farran-Teixidó, Sebastiano Biondo, J. Llop-Talaveron, Elisabet Leiva-Badosa, R. Jódar-Masanés, Maria B. Badia-Tahull |
|---|---|
| Přispěvatelé: | Universitat de Barcelona |
| Rok vydání: | 2010 |
| Předmět: |
Male
Fish oils Parenteral Nutrition Medicine (miscellaneous) law.invention Postoperative Complications Anti-Infective Agents Randomized controlled trial law Ús terapèutic Programes de prevenció Medicine Prospective Studies Gastrointestinal system diseases Prospective cohort study Prevention programs Aged 80 and over Nutrition and Dietetics Incidence Incidence (epidemiology) Middle Aged Fish oil Malalties del tracte gastrointestinal Exact test Treatment Outcome Elective Surgical Procedures Anti-infective agents Female Emulsions Elective Surgical Procedure Adult Fat Emulsions Intravenous medicine.medical_specialty Agents antiinfecciosos Infections Sepsis Olis de peix Postoperative care Fish Oils Double-Blind Method Humans Plant Oils Olive Oil Aged Cirurgia business.industry Therapeutic use medicine.disease Surgery Gastrointestinal Tract Cura postoperatòria Parenteral nutrition Alimentació parenteral Parenteral feeding business |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona Recercat. Dipósit de la Recerca de Catalunya instname |
| ISSN: | 1475-2662 0007-1145 |
| DOI: | 10.1017/s0007114510001066 |
| Popis: | n-3 Fatty acids have clinical benefits. The primary aim of the present study was the assessment of infection in patients who underwent major high-risk elective gastrointestinal surgery receiving postoperatively fish oil (FO)-supplemented parenteral nutrition (PN), compared with those receiving a standard olive oil (OO) emulsion. The secondary aims were the assessment of anti-inflammatory response and evaluation of tolerance and safety of these emulsions. A prospective, randomised, double-blind study was performed in patients requiring at least 5 d of PN. An isoenergetic and isoproteic formula was administered: group A received OO alone, while group B received OO that was partially replaced with FO (16·6 %, w/w). End points were outcome measures (mortality, sepsis, infection, hospitalisation days and PN duration), inflammatory response (C-reactive protein (CRP), prealbumin and leucocytes) and safety (TAG and glucose metabolism, and liver and kidney function). Statistical analysis was done using Student's t test and Fisher's exact test (P v. 78·6 %, P = 0·007). CRP, prealbumin and leucocytes were not significantly different between the groups. There were no differences in safety parameters. We conclude that high-risk surgical patients receiving FO-supplemented PN for 5 d present a lower incidence of infection. Emulsions were safe and well tolerated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|