Prospective, multicenter study of managing lower extremity venous ulcers
| Autor: | Roger Allen, Thomas E. Arnold, James C. Stanley, C.F.H. Vickers, Laura Bolton, Jerry J. Hutchinson, Georgia A. Moncada, Elaine P. Fellows, William M. Swartz, Morris D. Kerstein |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Treatment response Time Factors Treatment outcome Pain Varicose Ulcer medicine Humans In patient Colloids Prospective Studies Aged Hydrocolloid dressing Leg Wound Healing business.industry Remission Induction General Medicine Middle Aged Compression therapy Bandages Surgery Multicenter study Patient Satisfaction Female Zinc Oxide Cardiology and Cardiovascular Medicine business Abdominal surgery Follow-Up Studies |
| Zdroj: | Annals of vascular surgery. 8(4) |
| ISSN: | 0890-5096 |
| Popis: | Seventy patients with 90 venous ulcers were randomly assigned to hydrocolloid or conventional dressing and compression therapy at four study centers. The ulcers had been present for a mean of 47.8 in the control and 46.2 weeks in the treatment group and 42% of all patients had recurrent ulcers. Ulcers treated with hydrocolloid dressings reduced 71% and control treated wounds reduced 43% in area after 7.2 weeks of treatment. Thirty-four percent of all ulcers healed. Mean time to healing was 7 weeks for the hydrocolloid dressing group and 8 weeks for the control group. Most ulcers were less painful at final evaluation, but reduction in pain was more pronounced in hydrocolloid-dressed ulcers (p = 0.03). At baseline as well as during follow-up, significant differences between study centers were observed. Ulcers in patients in the United Kingdom were larger and less likely to heal (p = 0.001). Size of the ulcer at baseline was associated with treatment response and time to healing (p = 0.002). Percent reduction in ulcer area after 2 weeks was also correlated with treatment outcome (p = 0.004) and time to healing (p = 0.002). When all treatment outcome predictors were analyzed together, only percent reduction in area after 2 weeks remained statistically significant (p = 0.002), with percent reduction during the first 2 weeks of treatment30% predicting healing. |
| Databáze: | OpenAIRE |
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