Time course of the spasmolytic effect of cadmium and cadmium uptake in guinea-pig taenia coli
| Autor: | Hiroshi Koshiba, Tetsuyuki Nasu |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
Colon Guinea Pigs chemistry.chemical_element In Vitro Techniques Inhibitory postsynaptic potential Guinea pig Smooth muscle medicine Animals Cysteine Edetic Acid Pharmacology Cadmium Muscle Smooth Taenia coli Molecular biology Surface membrane medicine.anatomical_structure chemistry Biochemistry Time course Potassium Muscle Contraction |
| Zdroj: | General Pharmacology: The Vascular System. 15:67-70 |
| ISSN: | 0306-3623 |
| Popis: | o 1. 1. The relationship between tension inhibitory action of cadmium and cadmium uptake was investigated in the smooth muscle of taenia coli. 2. 2. Following a treatment with 0.5 mM Cd 2+ for short periods (1, 5 min), the tension to high-K + returned to a greater extent after washing with disodium edetate (EDTA) or cysteine, compared to normal medium. 3. 3. However, the restored tension to the high-K + decreased with increasing duration of Cd 2+ treatment. 4. 4. With a longer duration of 0.5 mM Cd 2+ treatment, the cadmium uptake increased and the size of cadmium fraction bound to cells firmly increased. 5. 5. It is suggested that Cd 2+ binds initially to the surface membrane of taenia coli and that Cd 2+ subsequently migrates to a compartment that EDTA cannot reach. |
| Databáze: | OpenAIRE |
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