Zoonotic Alphaviruses in Fatal and Neurologic Infections in Wildlife and Nonequine Domestic Animals, South Africa
| Autor: | J.H. Williams, Stefanie van Niekerk, Jumari Steyn, Johan Christian Abraham Steyl, Elizabeth Botha, Bjorn Reininghaus, Voula Stivaktas, Isabel Fourie, Marietjie Venter |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Sindbis virus Epidemiology Middelburg virus wildlife viruses Alphaviruses 030231 tropical medicine Wildlife Neurologic Signs lcsh:Medicine Animals Wild neurologic infections lcsh:Infectious and parasitic diseases 03 medical and health sciences South Africa 0302 clinical medicine Phylogenetics medicine Animals lcsh:RC109-216 030212 general & internal medicine Horses Neurologic disease Alphavirus infection Phylogeny nonequine domestic animals biology Host (biology) Research lcsh:R biology.organism_classification medicine.disease Virology Zoonotic Alphaviruses in Fatal and Neurologic Infections in Wildlife and Nonequine Domestic Animals South Africa zoonoses Infectious Diseases Animals Domestic meningitis/encephalitis |
| Zdroj: | Emerging Infectious Diseases, Vol 26, Iss 6, Pp 1182-1191 (2020) Emerging Infectious Diseases |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | Alphaviruses from Africa, such as Middelburg virus (MIDV), and Sindbis virus (SINV), were detected in horses with neurologic disease in South Africa, but their host ranges remain unknown. We investigated the contribution of alphaviruses to neurologic infections and death in wildlife and domestic animals in this country. During 2010-2018, a total of 608 clinical samples from wildlife and nonequine domestic animals that had febrile, neurologic signs or unexplained deaths were tested for alphaviruses. We identified 32 (5.5%) of 608 alphavirus infections (9 SINV and 23 MIDV), mostly in neurotissue of wildlife, domestic animals, and birds. Phylogenetic analysis of the RNA-dependent RNA polymerase gene confirmed either SINV or MIDV. This study implicates MIDV and SINV as potential causes of neurologic disease in wildlife and nonequine domestic species in Africa and suggests a wide host range and pathogenic potential. |
| Databáze: | OpenAIRE |
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