Differential effects of subcutaneous estrogen and progesterone on low-density lipoprotein size and susceptibility to oxidation in postmenopausal rhesus monkeys
| Autor: | Phillip E. Patton, David L. Wheaton, P. Barton Duell, Kenneth A. Burry, Harold G. Spies, Karen A. McKinney, David L. Hess |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class chemistry.chemical_compound Internal medicine biology.animal medicine Animals Primate Longitudinal Studies Prospective Studies Progesterone Estradiol biology Cholesterol Obstetrics and Gynecology medicine.disease Macaca mulatta Differential effects Lipoproteins LDL Postmenopause Menopause Endocrinology Reproductive Medicine chemistry Estrogen Low-density lipoprotein Female Biomedical sciences Lipoprotein |
| Zdroj: | Fertility and Sterility. 68:525-530 |
| ISSN: | 0015-0282 |
| Popis: | Objective: To study the differential effects of subcutaneous E 2 alone or in combination with P on the susceptibility of low-density lipoprotein (LDL) cholesterol to oxidation in naturally postmenopausal diet-controlled rhesus monkeys. Design: Prospective, longitudinal controlled study. Setting: Oregon Health Sciences University, Portland, Oregon, and Oregon Regional Primate Research Center, Beaverton, Oregon. Patient(s): Five naturally postmenopausal rhesus monkeys. Intervention(s): Estradiol was administered subcutaneously for the first 4 weeks, followed by E 2 plus P for 4 weeks, followed by a third 4-week washout period. Main Outcome Measure(s): Changes in plasma lipoprotein levels and oxidation of LDL and serum concentrations of E 2 and P. Result(s): Levels of LDL cholesterol fell after 4 weeks of treatment with E 2 , compared with baseline. The lag time to half maximal light absorbancy after 4 weeks of E 2 treatment was significantly increased compared with baseline. The maximal absorbance values and the slope of the propagation phase after 4 weeks of treatment with E 2 were decreased compared with baseline. After 4 weeks of combined E 2 and P treatment, all values were comparable to baseline. Conclusion(s): These results suggest that subcutaneous E 2 therapy appears to enhance LDL resistance to oxidation and that this effect is attenuated by the addition of the P. |
| Databáze: | OpenAIRE |
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