Development and bioevaluation of (o)-82Br[77Br]-bromohippuran
| Autor: | F.J. Haasbroek, D. Niemann, P. Bekker, A.J. van Wyk, H. Roesch, S.S.J. Venter, P.J. Fourie |
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| Rok vydání: | 1983 |
| Předmět: |
Radioisotopes
Pathology medicine.medical_specialty Radiation business.industry Follow up studies Pharmacology Bromine Clinical trial Mice Nuclear Energy and Engineering Iodohippuran In vivo Isotope Labeling Medicine Animals Radiology Nuclear Medicine and imaging Iodohippuric Acid Tissue Distribution Rabbits Whole body business |
| Zdroj: | The International journal of applied radiation and isotopes. 34(7) |
| ISSN: | 0020-708X |
| Popis: | We show that ( o )-[ 82/77 Br]bromohippuran ([ 82/77 Br]-C 6 H 4 CONHCH 2 COONa) with unlabelled ( o )-iodohippuran (I-C 6 H 4 CONHCH 2 COONa) as carrier has in vivo properties analogous to ( o )-[ 131 I]iodohippuran in rabbits and mice, while 77 Br has some chemical, nuclidic and physiological advantages over 131 I. This particular study was sufficiently encouraging to warrant a separate follow up study, currently in progress, with more advanced investigations on animals, while the main objective is eventual clinical trials, including whole body dosimetry studies. |
| Databáze: | OpenAIRE |
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