Too Late Prenatal Diagnosis of Fetal Toxoplasmosis: A Case Report
| Autor: | Krzysztof Szaflik, Dorota Nowakowska, Jan Wilczyński, Tadeusz H Dzbeński, Maria Respondek-Liberska, Babill Stray-Pedersen, Elzbieta Gołab |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Embryology medicine.medical_specialty Pediatrics Choroiditis Time Factors Antiprotozoal Agents Leucovorin Retinitis Prenatal diagnosis macromolecular substances Severity of Illness Index Toxoplasmosis Congenital Ultrasonography Prenatal Mice Muscular Diseases Pregnancy Seizures Sulfadoxine medicine Animals Humans Radiology Nuclear Medicine and imaging Brain Diseases Fetus business.industry Infant Newborn Calcinosis Obstetrics and Gynecology Gestational age General Medicine Amniotic Fluid medicine.disease Toxoplasmosis Immunoglobulin A nervous system diseases Surgery Hydrocephalus Drug Combinations Pyrimethamine Immunoglobulin M Pediatrics Perinatology and Child Health Gestation Female business Toxoplasma |
| Zdroj: | Fetal Diagnosis and Therapy. 20:190-193 |
| ISSN: | 1421-9964 1015-3837 |
| DOI: | 10.1159/000083903 |
| Popis: | Objective: We describe a case of severe fetal hydrocephalus due to toxoplasmosis which could not be diagnosed until late gestational age due to the lack of a serologic surveillance program during pregnancy; moreover, this case points to the usefulness of molecular biology tools in the diagnostic process. Abnormal ultrasound in the 2ndtrimester was noticed and Toxoplasma gondii was demonstrated in amniotic fluid at the 28th week of gestation both by PCR and by mice inoculation. Fansidar and folinic acid were administered. The newborn suffered from progressive hydrocephalus, seizures, and pathological muscular tonus; ultrasound examination showed massive cerebral calcifications. Ophthalmologic examination revealed bilateral choroidoretinitis. Congenital toxoplasmosis was confirmed by the detection of anti- T. gondii IgM and IgA in the neonatal serum. Conclusion: The presented case is an example of severe fetal toxoplasmosis diagnosed and treated in utero. |
| Databáze: | OpenAIRE |
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