Hyperhomocysteinaemia in stroke: prevalence, cause, and relationships to type of stroke and stroke risk factors
| Autor: | Arne Lindgren, Bo Israelsson, A. Hamfelt, Bo Norrving, B. Upson, M. R. Malinow, Lars Brattström |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Lacunar stroke Homocysteine Clinical Biochemistry Renal function Fibrinogen Biochemistry chemistry.chemical_compound Folic Acid Risk Factors Internal medicine Carotid artery disease Medicine Humans cardiovascular diseases Risk factor Stroke Aged Aged 80 and over Creatinine business.industry Age Factors General Medicine Middle Aged medicine.disease Cerebrovascular Disorders Vitamin B 12 Endocrinology chemistry Pyridoxal Phosphate Cardiology Female business medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0014-2972 |
| Popis: | Moderate hyperhomocysteinaemia is a frequent finding in atherothrombotic cerebrovascular disease. This study confirms and extends this observation. Hyperhomocysteinaemia was present in 57 of 142 survivors with stroke (40%) and in four of 66 controls (6%). Plasma homocysteine concentrations were increased not only in carotid artery disease or lacunar stroke but also in haemorrhagic or embolic strokes. Homocysteine values were unrelated to the presence of hypertension, smoking, or hypercholester-olaemia, or to the concentrations of blood glucose, glycosylated haemoglobin, and plasma fibrinogen. Multiple regression analysis of the patient data showed that about 40% of the variation in plasma homocysteine concentrations could be predicted by the values for the homocysteine metabolism cofactors, blood folate and plasma pyridoxal 5-phosphate and by renal function as reflected in the values for serum creatinine. In patients, urine excretion of homocysteine per unit creatinine was significantly increased and strongly correlated both to the plasma homocysteine concentration and to the values for blood folate, plasma pyridoxal 5-phosphate, and serum vitamin B12. We conclude that moderate hyperhomocysteinaemia is frequently present in cases of stroke, is independent of other stroke risk factors or the type of stroke, and is partly related to renal function and the concentrations of homocysteine metabolism cofactors. |
| Databáze: | OpenAIRE |
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