Goniothalamin Inhibits Growth of Human Lung Cancer Cells through DNA Damage, Apoptosis, and Reduced Migration Ability
| Autor: | Chien-Chih Chiu, Yang Chang Wu, Inn Wen Chong, Fang Rong Chang, Kuang Jing Huang, Jia Shing Chen, Po Len Liu, Hui Min Wang, Hsueh-Wei Chang, Kuo Feng Chang, Kang Fang, Chon-Kit Chou |
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| Rok vydání: | 2011 |
| Předmět: |
Lung Neoplasms
DNA damage Cell Apoptosis Biology chemistry.chemical_compound Cell Movement Carcinoma Non-Small-Cell Lung Cell Line Tumor medicine Humans Lung cancer Cancer General Chemistry medicine.disease Antineoplastic Agents Phytogenic Comet assay medicine.anatomical_structure chemistry Pyrones Cell culture Immunology cardiovascular system Cancer research Comet Assay Growth inhibition General Agricultural and Biological Sciences Cell Division DNA Damage circulatory and respiratory physiology |
| Zdroj: | Journal of Agricultural and Food Chemistry. 59:4288-4293 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/jf200566a |
| Popis: | We evaluated the possible anticancer performance of a natural compound, goniothalamin (GTN), against human lung cancer using as a non-small cell lung cancer (NSCLC) cell line, H1299, as the model system. Cellular proliferation was significantly inhibited by GTN. Using an improved alkaline comet-nuclear extract (comet-NE) assay, GTN was found to induce a significant increase in the tail DNA. Wound healing and zymography assays showed that GTN attenuated cell migration and caused a reduction in the activity level of two major migration-associated matrix metalloproteinases, MMP-2 and MMP-9. It can be concluded that the DNA-damaging effect of GTN against lung cancer cells leads to growth inhibition as well as a depression in migration ability. Therefore, GTN has potential as a chemotherapeutic agent against lung cancer. |
| Databáze: | OpenAIRE |
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