Hyperhomocysteinaemia in HIV-infected patients: determinants of variability and correlations with predictors of cardiovascular disease
| Autor: | Nicola Squillace, Giulia Nardini, Elisa Garlassi, Gabriella Orlando, Paolo Ventura, Stefano Marchini, Giovanni Guaraldi, Valeria Moriondo, Stefano Zona, Pablo Tebas, Chiara Stentarelli |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Homocysteine Hyperhomocysteinemia Blood lipids HIV Infections Risk Assessment Gastroenterology chemistry.chemical_compound Insulin resistance Predictive Value of Tests Antiretroviral Therapy Highly Active Internal medicine medicine Humans Pharmacology (medical) Prospective Studies Metabolic Syndrome Anthropometry biology business.industry HIV-Associated Lipodystrophy Syndrome Health Policy medicine.disease Cross-Sectional Studies Infectious Diseases Blood pressure Endocrinology chemistry Cardiovascular Diseases HIV-1 Lean body mass biology.protein Female Apolipoprotein A1 Metabolic syndrome Lipodystrophy business Biomarkers |
| Zdroj: | HIV Medicine. 10:28-34 |
| ISSN: | 1468-1293 1464-2662 |
| DOI: | 10.1111/j.1468-1293.2008.00649.x |
| Popis: | Objective We evaluated hyperhomocysteinaemia (HHcy) in a cohort of HIV-infected patients in order to assess its relation to cardiovascular risk (CVR) and identify determinants of HHcy variability. Methods Cross-sectional observational study. HIV-infected patients on stable highly active antiretroviral therapy (ART) were evaluated for the presence of the metabolic syndrome, lipodystrophy and traditional CVR factors. Plasma homocysteine levels were measured using high-performance liquid chromatography. Results Five hundred and sixty-seven patients (38% female) with a median age of 44 years were included in the study. Homocysteine (Hcy) was significantly higher in patients with the metabolic syndrome and lipodystrophy. No significant association was found between Hcy levels and the use of ART. However, Hcy was associated with higher blood pressure, waist circumference and waist-to-hip ratio, total lean body mass, visceral adipose tissue (VAT), VAT/total adipose tissue, homeostasis model assessment of insulin resistance (HOMA-IR), triglycerides, high-density lipoprotein cholesterol, apolipoprotein A1, B, and creatinine. All 10-year CVR assessment scores were significantly associated with Hcy. In a multivariate regression model, systolic blood pressure, vitamin supplementation and HOMA-IR were significantly and independently related to Hcy. Conclusions Hcy is elevated in HIV-infected patients and is significantly associated with increased CVR. Measurement of Hcy might be useful in identifying particularly high-risk populations at whom therapeutic interventions could be targeted. |
| Databáze: | OpenAIRE |
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