Kinetics of Lymphocyte Apoptosis in Macaques Infected with Different Simian Immunodeficiency Viruses or Simian/Human Immunodeficiency Hybrid Viruses
| Autor: | Gerhard Hunsmann, Stefanie Reinberger, Dittmer U, Thomas Nißlein, Christiane Stahl-Hennig, Michael Spring |
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| Rok vydání: | 1999 |
| Předmět: |
CD4-Positive T-Lymphocytes
Programmed cell death T-Lymphocytes animal diseases viruses Immunology Cell Apoptosis HIV Infections CD8-Positive T-Lymphocytes Biology Simian Peripheral blood mononuclear cell T-Lymphocyte Subsets Increased lymphocyte apoptosis medicine Animals Humans Immunology and Allergy Immunodeficiency Cell Cycle virus diseases T-Lymphocytes Helper-Inducer medicine.disease biology.organism_classification Macaca mulatta Virology medicine.anatomical_structure HIV-1 Simian Immunodeficiency Virus CD8 |
| Zdroj: | Clinical Immunology. 90:141-146 |
| ISSN: | 1521-6616 |
| DOI: | 10.1006/clim.1998.4630 |
| Popis: | Increased rates of T-cell apoptosis have been detected in human immunodeficiency virus (HIV)-infected individuals and in the simian immunodeficiency model (SIV) for AIDS research. We have infected macaques with virulent SIV or SIV/HIV hybrid viruses (SHIV) of different pathogenic potentials to study the early kinetics of apoptosis in this model. Animals infected with SIV showed an increased degree of apoptosis in their peripheral blood mononuclear cells as early as 8 weeks after virus inoculation. Apoptotic cells were detected in the CD4 and CD8 cell populations of infected animals. In contrast, apathogenic SHIV did not lead to increased lymphocyte apoptosis and moderately pathogenic SHIV induced only transient apoptosis. T-cell death was temporally linked to viral replicationin vivo.Furthermore, lymphocyte apoptosis in infected macaques was associated with impaired proliferative responses of helper T-cells and with CD4 cell depletion. The monkey model described here provides the opportunity for testing early therapeutic interventions to prevent virus-induced programmed cell death and the subsequent onset of AIDS. |
| Databáze: | OpenAIRE |
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