Genetic associations between the miRNA polymorphisms miR-130b (rs373001), miR-200b (rs7549819), and miR-495 (rs2281611) and colorectal cancer susceptibility
| Autor: | Hak Hoon Jun, Jisu Oh, Han Sung Park, Jong Woo Kim, Eun-Gyo Kim, Nam Keun Kim, Chang Soo Ryu, Jung Oh Kim |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Male Cancer Research medicine.medical_specialty Colorectal cancer Single-nucleotide polymorphism lcsh:RC254-282 Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Surgical oncology Internal medicine Genotype Genetics medicine Humans Genetic Predisposition to Disease Survival analysis Genetic Association Studies Genetic association Aged business.industry Hazard ratio Odds ratio Middle Aged medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Survival Analysis MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Case-Control Studies Multivariate Analysis Female business Colorectal Neoplasms Research Article |
| Zdroj: | BMC Cancer BMC Cancer, Vol 19, Iss 1, Pp 1-9 (2019) |
| ISSN: | 1471-2407 |
| Popis: | Background Recent studies have extensively investigated the role of miRNAs in colorectal cancer (CRC), and several associations have been reported. In addition, single nucleotide polymorphisms (SNPs) in promoter regions of miRNAs have been shown to affect miRNA expression. Therefore, we aimed to analyze the effect of miRNA polymorphisms on CRC susceptibility. Methods We conducted association studies on the relationships between the miRNA polymorphisms miR-130bT > C rs373001, miR-200bT > C rs7549819, and miR-495A > C rs2281611 and CRC with 472 CRC patients and 399 control subjects in Korea. Results Multivariate logistic regressions of the CRC subgroups showed that the miR-495CC genotype associated with rectal cancer (AA+AC vs. CC; adjusted odds ratio (AOR) for CC, 1.592; 95% confidence interval (CI), 1.071–2.368; P = 0.022). The gene-environment combinatorial analysis showed that the combination of miR-495A > C and low plasma folate contributed to an increased risk of rectal cancer (AA+AC vs. CC; AOR for CC, 3.829; 95% CI, 1.577–9.300; P = 0.003). In the survival analysis, miR-200bT > C associated with CRC patient mortality (TT vs TC + CC; adjusted hazard ratio for TC + CC, 0.592; 95% CI, 0.373–0.940; P = 0.026). Conclusion In this study, we found that miR-200b and miR-495 polymorphisms are involved in CRC susceptibility and prognosis. Electronic supplementary material The online version of this article (10.1186/s12885-019-5641-1) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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