Effect of different exposure times on physicochemical, mechanical and biological properties of PGS scaffolds treated with plasma of iodine-doped polypyrrole
| Autor: | J Manuel Cervantes-Uc, Fernando Hernández-Sánchez, Alejandro Ávila-Ortega, Gaspar Eduardo Martín-Pat, H. J. Carrillo-Escalante, Angela F Ku-Gonzalez, Raúl Rosales-Ibáñez, Nayeli Rodríguez-Fuentes |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Glycerol
Time Factors Plasma Gases Cell Survival Polymers Surface Properties Biomedical Engineering Biocompatible Materials Polypyrrole Biomaterials Contact angle chemistry.chemical_compound X-ray photoelectron spectroscopy Humans Pyrroles Viability assay Fourier transform infrared spectroscopy Cytotoxicity Dental Pulp Cell Proliferation Tissue Engineering Tissue Scaffolds Stem Cells Decanoates Plasma Cross-Linking Reagents chemistry Mechanical Tests lipids (amino acids peptides and proteins) Leaching (metallurgy) Iodine Nuclear chemistry |
| Zdroj: | Journal of Biomaterials Applications. 35:485-499 |
| ISSN: | 1530-8022 0885-3282 |
| Popis: | Polyglycerol sebacate (PGS) scaffolds obtained using a leaching technique were modified with iodine-doped polypyrrole (PPy-I) in a plasma reactor in order to study the effect of exposure time on the cell viability of hDPSCs. SEM analysis showed the formation and growth of PPy-I particles as the exposure time was increased, while FTIR and XPS analysis revealed the presence of -NH- and N+ groups in the chemical composition of the surfaces, relating to the increase in the amount of PPY-I particles. The water contact angle measurements showed an increase in the scaffold’s hydrophilicity with greater exposure times which was also attributed to the rising of PPy-I particles. It was also observed that PPy-I promotes the rigidity of the treated PGS scaffolds. when in direct contact with treated PGS scaffolds, cell viability improved with respect to non-treated scaffolds, however only at shorter time exposures. Extracts of plasma-treated PGS scaffolds showed high cytotoxicity as the time exposure to plasma treatment was increased. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|