Early exposure to Aroclor 1254in vivodisrupts the functional synaptic development of newborn hippocampal granule cells
| Autor: | aesoon bensen, Christopher E. Vaaga, Anneline Pinson, Nicholas I. Woods, Jean-Pierre Bourguignon, Arlette Gerard, Jean-Pierre Thomé, Gary L. Westbrook, Christina Chatzi, Anne-Simone Parent |
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| Rok vydání: | 2016 |
| Předmět: |
Thyroid Hormones
medicine.medical_specialty Cell Survival Neurogenesis Synaptogenesis Endogeny 010501 environmental sciences Biology Hippocampal formation Hippocampus 01 natural sciences Article Mice 03 medical and health sciences 0302 clinical medicine Pregnancy In vivo Internal medicine medicine Animals Cell Proliferation 0105 earth and related environmental sciences Neurons General Neuroscience Dentate gyrus Excitatory Postsynaptic Potentials Chlorodiphenyl (54% Chlorine) Mice Inbred C57BL Endocrinology Prenatal Exposure Delayed Effects Synapses Excitatory postsynaptic potential Gestation Female Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Neuroscience. 44:3001-3010 |
| ISSN: | 0953-816X |
| Popis: | Neurogenesis in the dentate gyrus is sensitive to endogenous and exogenous factors that influence hippocampal function. Ongoing neurogenesis and the integration of these new neurons throughout life thus may provide a sensitive indicator of environmental stress. We examined the effects of Aroclor 1254 (A1254), a mixture of polychlorinated biphenyls (PCBs), on the development and function of newly generated dentate granule cells. Early exposure to A1254 has been associated with learning impairment in children, suggesting potential impact on the development of hippocampus and/or cortical circuits. Oral A1254 (from the 6th day of gestation to postnatal day 21) produced the expected increase in PCB levels in brain at postnatal day 21, which persisted at lower levels into adulthood. A1254 did not affect the proliferation or survival of newborn neurons in immature animals nor did it cause overt changes in neuronal morphology. However, A1254 occluded the normal developmental increase in sEPSC frequency in the third post-mitotic week without altering the average sEPSC amplitude. Our results suggest that early exposure to PCBs can disrupt excitatory synaptic function during a period of active synaptogenesis, and thus could contribute to the cognitive effects noted in children exposed to PCBs. |
| Databáze: | OpenAIRE |
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