PCAT-1: A Novel Oncogenic Long Non-Coding RNA in Human Cancers
| Autor: | Jianfa Li, Tiefu Xiong, Fangfang Chen, Fangting Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Carcinoma
Hepatocellular Colorectal cancer Review Biology Applied Microbiology and Biotechnology 03 medical and health sciences Prostate cancer medicine cancer Animals Humans Molecular Biology Ecology Evolution Behavior and Systematics 030304 developmental biology Cell Proliferation Protein coding 0303 health sciences long non-coding RNA Wnt signaling pathway Cancer therapeutic target Cell Biology medicine.disease Long non-coding RNA Biomarker (cell) Gene Expression Regulation Neoplastic Apoptosis Cancer research biomarker RNA Long Noncoding PCAT-1 Biomarkers Developmental Biology |
| Zdroj: | International Journal of Biological Sciences |
| ISSN: | 1449-2288 |
| Popis: | Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides (nts) without obvious protein coding potential. lncRNAs act as multiple roles in biological processes of diseases, especially carcinomas. Prostate cancer associated transcript-1 (PCAT-1) is an oncogenic lncRNA that identified by RNA-Sequence in prostate cancer. High expression of PCAT-1 is observed in different types of cancers, including prostate cancer, colorectal cancer, hepatocellular cancer and gastric cancer. High expressed PCAT-1 is correlated with poor overall survival. Furthermore, PCAT-1 regulates cancer cell proliferation, apoptosis, migration and invasion. Additionally, PCAT-1 is involved in EMT and Wnt/β-catenin-signaling pathway. In this review, we focus on the implication of PCAT-1 in human cancers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|