Synthesis and biological evaluation of novel podophyllotoxin analogs as antitumor agents

Autor:	Jing Zhou, Hong Chen, Gang Luo, Li-Ming Zhang, Zhong-Heng Zhang, Shi Zhang
Rok vydání:	2014
Předmět:	Stereochemistry Imine Pharmaceutical Science Antineoplastic Agents Analytical Chemistry HeLa chemistry.chemical_compound Structure-Activity Relationship Drug Discovery medicine Humans MTT assay Nuclear Magnetic Resonance Biomolecular Etoposide Podophyllotoxin Pharmacology Indole test biology Molecular Structure Organic Chemistry General Medicine biology.organism_classification In vitro Complementary and alternative medicine chemistry Biochemistry Cell culture Molecular Medicine Drug Screening Assays Antitumor K562 Cells medicine.drug K562 cells HeLa Cells
Zdroj:	Journal of Asian natural products research. 16(5)
ISSN:	1477-2213
Popis:	A series of 4β N-indole-substituted podophyllotoxin derivatives were synthesized. Nine target compounds were evaluated against human cancer cell lines (HeLa, K562, and K562/A02) using MTT assay including three imine derivatives 8, 9, and 10 in vitro. The result showed that the three compounds had higher antitumor activity than their reduced forms. Among them, compounds 8, 9, 11, and 16 were superior to the positive control VP-16.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a8d26e8cadb4ac6a8397432632143f https://pubmed.ncbi.nlm.nih.gov/24824554 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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