Relationship Between CT Volumetry and Functional Liver Volume Using Technetium-99m Galactosyl Serum Albumin Scintigraphy in Patients Undergoing Preoperative Portal Vein Embolization Before Major Hepatectomy: A Preliminary Study
| Autor: | Hiroyuki Yamaguchi, Atsushi Nanashima, Takashi Tsuji, Shinichi Shibasaki, Noboru Ide, Hiroaki Takeshita, Terumitsu Sawai, Shigeyuki Morino, Tohru Nakagoe, Youji Ogawa, Takeshi Nagayasu |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Carcinoma Hepatocellular Cirrhosis Physiology medicine.medical_treatment Serum albumin chemistry.chemical_element Technetium Scintigraphy Preoperative care Cholangiocarcinoma Japan Preoperative Care medicine Hepatectomy Humans Embolization Radionuclide Imaging Technetium Tc 99m Aggregated Albumin Aged biology medicine.diagnostic_test Portal Vein business.industry Liver Diseases Liver Neoplasms Gastroenterology Middle Aged medicine.disease Combined Modality Therapy Embolization Therapeutic Bile Ducts Intrahepatic Treatment Outcome Bile Duct Neoplasms Liver chemistry biology.protein Female Radiology Radiopharmaceuticals business Nuclear medicine Tomography Spiral Computed Technetium-99m |
| Zdroj: | Digestive Diseases and Sciences. 51:1190-1195 |
| ISSN: | 1573-2568 0163-2116 |
| DOI: | 10.1007/s10620-006-8031-x |
| Popis: | To clarify the relationship between morphological measurements of hepatic volume by computed tomography (CT-vol) and functional volume (RI-vol) by technetium-99m galactosyl human serum albumin (99mTc-GSA) scintigraphy, and its clinical significance, we examined 16 patients with a background liver status of either normal liver function (n = 4), chronic hepatitis or cirrhosis (n = 7), or obstructive jaundice (n = 5). In five patients who underwent preoperative portal vein embolization (PVE), volumetric measurement was performed 2 weeks after PVE. The mean values of CT-vol and RI-vol of the right lobe were 692± 147 cm3 (66.1 ± 10.7%) and 668 ± 159 cm3 (67.8 ± 13.2%), respectively, and those of the left lobe were 329 ± 138 cm3 (33.9 ± 10.6%) and 328± 170 cm3 (32.2 ± 13.2%), respectively. There were no significant differences in the volume measurements between the two volumetric techniques. Correlations between CT-vol and RI-vol in the right and left lobes were positive and significant (r = 0.912 and 0.903, respectively; both P′s < 0.001). The mean values of post-PVE CT-vol and RI-vol of the right lobe in five patients were significantly different (628 ± 149 and 456± 211 cm3, respectively; P = 0.033). However, the mean values of post-PVE CT-vol and RI-vol of the left lobe were not different (496 ± 124 and 483± 129 cm3, respectively). We propose that volumetric measurement by 99mTc-GSA scintigraphy is useful for detecting changes in functional volume of individual lobes of the liver and is a more dynamic method compared with detection of morphological changes by CT scan. |
| Databáze: | OpenAIRE |
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