Diabetes and Prediabetes in Children With Cystic Fibrosis: A Systematic Review of the Literature and Recommendations of the Italian Society for Pediatric Endocrinology and Diabetes (ISPED)
| Autor: | Stefano Zucchini, Donatella Lo Presti, Riccardo Schiaffini, Valentino Cherubini, Dorina Pjetraj, Claudia Piona, Fortunato Lombardo, Valeria Calcaterra, Anna Paola Frongia, Sonia Toni, M. C. Matteoli, Giuseppe d'Annunzio, Vittoria Cauvin, Elvira Piccinno, Andrea Scaramuzza, Barbara Predieri, Claudio Maffeis, Giulio Maltoni, Enza Mozzillo, Alberto Casertano, Ivana Rabbone, Roberto Franceschi, Stefano Passanisi, Adriana Franzese |
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| Přispěvatelé: | Mozzillo, E., Franceschi, R., Piona, C., Passanisi, S., Casertano, A., Pjetraj, D., Maltoni, G., Calcaterra, V., Cauvin, V., Cherubini, V., D'Annunzio, G., Franzese, A., Frongia, A. P., Lombardo, F., Lo Presti, D., Matteoli, M. C., Piccinno, E., Predieri, B., Rabbone, I., Scaramuzza, A. E., Toni, S., Zucchini, S., Maffeis, C., Schiaffini, R. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
recommendation Pediatrics medicine.medical_specialty Cystic Fibrosis Pediatric endocrinology Endocrinology Diabetes and Metabolism cystic fibrosis-related diabete Cystic fibrosis-related diabetes cystic fibrosis-related diabetes 030209 endocrinology & metabolism Review prediabetes Cystic fibrosis Diseases of the endocrine glands. Clinical endocrinology Prediabetic State 03 medical and health sciences 0302 clinical medicine Endocrinology abnormal glucose tolerance continuous glucose monitoring glargine insulin oral glucose tolerance test (OGTT) recommendations systematic review Diabetes mellitus medicine Diabetes Mellitus Humans Hypoglycemic Agents Insulin 030212 general & internal medicine Prediabetes Glycemic Insulin glargine business.industry Glucose Tolerance Test RC648-665 medicine.disease Prognosis Comorbidity Disease Progression prediabete business medicine.drug |
| Zdroj: | Frontiers in Endocrinology Frontiers in Endocrinology, Vol 12 (2021) |
| Popis: | Cystic fibrosis related diabetes (CFRD) is a comorbidity of cystic fibrosis (CF) that negatively impacts on its clinical course. Prediabetes is an important predictor of either CFRD development and unfavorable prognosis of CF in both pediatric and adult patients. International guidelines recommend insulin only in case of CFRD diagnosis. Whether early detection and treatment of prediabetes may contribute to improve the clinical course of CF is still debated. A subgroup of pediatric diabetologists of the Italian Society for Pediatric Endocrinology and Diabetology (ISPED) performed a systematic review of the literature based on predefined outcomes: impact of pre-diabetes on clinical outcomes and on the risk of developing CFRD; diagnosis of diabetes and pre-diabetes under 10 years of age; effectiveness of therapy on glycemic control, impact of therapy on pulmonary function and nutritional status. Thirty-one papers were selected for the analysis data presented in these papers were reported in tables sorted by outcomes, including comprehensive evidence grading according to the GRADE approach. Following the grading of the quality of the evidence, the entire ISPED diabetes study group achieved consensus for the Italian recommendations based on both evidence and clinical experience. We concluded that in patients with CF, prediabetes should be carefully considered as it can evolve into CFRD. In patients with CF and prediabetic conditions, after complete evaluation of the OGTT trend, glucometrics, glycemic values measured during pulmonary exacerbations and/or steroid therapy, early initiation of insulin therapy could have beneficial effects on clinical outcomes of patients with CF and prediabetes. |
| Databáze: | OpenAIRE |
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