Potential Factors Influencing Repeated SARS Outbreaks in China
| Autor: | Karuppiah Thilakavathy, S. Suresh Kumar, Guozhong He, Zhong Sun, Shi V. Liu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Health
Toxicology and Mutagenesis coronavirus lcsh:Medicine ACE2 bat Disease Review drought 010501 environmental sciences medicine.disease_cause 01 natural sciences epidemic Disease Outbreaks Chiroptera Zoonoses Coronavirus risk green light 0303 health sciences Travel Ecology SARS-CoV red light host Severe acute respiratory syndrome-related coronavirus Social Conditions 2019-nCoV epidemiology Wuhan pneumonia Seasons Coronavirus Infections China Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) CoV wildlife Pneumonia Viral Wildlife severe acute respiratory syndrome Biology Peptidyl-Dipeptidase A 03 medical and health sciences angiotensin-converting enzyme 2 medicine Animals Humans 030304 developmental biology 0105 earth and related environmental sciences SARS outbreak lcsh:R COVID-19 infection exposure Public Health Environmental and Occupational Health Outbreak |
| Zdroj: | International Journal of Environmental Research and Public Health International journal of environmental research and public health, 17(5):1633 International Journal of Environmental Research and Public Health, Vol 17, Iss 5, p 1633 (2020) |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph17051633 |
| Popis: | Within last 17 years two widespread epidemics of severe acute respiratory syndrome (SARS) occurred in China, which were caused by related coronaviruses (CoVs): SARS-CoV and SARS-CoV-2. Although the origin(s) of these viruses are still unknown and their occurrences in nature are mysterious, some general patterns of their pathogenesis and epidemics are noticeable. Both viruses utilize the same receptor—angiotensin-converting enzyme 2 (ACE2)—for invading human bodies. Both epidemics occurred in cold dry winter seasons celebrated with major holidays, and started in regions where dietary consumption of wildlife is a fashion. Thus, if bats were the natural hosts of SARS-CoVs, cold temperature and low humidity in these times might provide conducive environmental conditions for prolonged viral survival in these regions concentrated with bats. The widespread existence of these bat-carried or -released viruses might have an easier time in breaking through human defenses when harsh winter makes human bodies more vulnerable. Once succeeding in making some initial human infections, spreading of the disease was made convenient with increased social gathering and holiday travel. These natural and social factors influenced the general progression and trajectory of the SARS epidemiology. However, some unique factors might also contribute to the origination of SARS in Wuhan. These factors are discussed in different scenarios in order to promote more research for achieving final validation. |
| Databáze: | OpenAIRE |
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