Pancreatic Damage after the First Episode of Acute Alcoholic Pancreatitis and Its Association with the Later Recurrence Rate
| Autor: | Hanna Pelli, Riitta Lappalainen-Lehto, Isto Nordback, Juhani Sand, Anneli Piironen, Satu Järvinen |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Alcohol Drinking Pancreatitis Alcoholic Endocrinology Diabetes and Metabolism Gastroenterology Atrophy Recurrent pancreatitis Recurrence Surveys and Questionnaires Internal medicine Glucose Intolerance Odds Ratio medicine Edema Humans Prospective Studies Risk factor skin and connective tissue diseases Prospective cohort study Pancreas Finland Aged Glycated Hemoglobin First episode Hepatology business.industry Calcinosis Odds ratio Middle Aged medicine.disease Magnetic Resonance Imaging Acute Disease Alcoholic pancreatitis Pancreatitis Female sense organs business Follow-Up Studies |
| Zdroj: | Pancreatology. 9:245-251 |
| ISSN: | 1424-3903 |
| Popis: | Acute alcoholic pancreatitis (AAP) recurs in up to half of the patients, continuous alcohol consumption being an important risk factor. Changes in pancreatic function and morphology after acute pancreatitis have been characterized previously, but their association with later recurrences has not been adequately studied.In this prospective follow-up study, the pancreatic function of 54 patients (47 males and 7 females) with a median age of 49 years (range 25-71) and morphology (35 patients) were evaluated. Pancreatic morphology was evaluated by secretin-stimulated magnetic resonance pancreatography (SMRP). Patients were evaluated early (baseline) and at 2 years after the first episode of AAP. In order to evaluate later recurrences, the patients were followed for a median of 47 (range 28-66) months.Of the 46 patients without previous diabetes, 17 patients (37%) developed impaired glucose metabolism during the 2 years following the first AAP. The prevalence of exocrine dysfunction decreased from 39% at baseline to 9% at 2 years. Of the patients with severe pancreatitis (n = 13, 24%), 31% had elevated glycosylated haemoglobin levels compared to 7% in patients with mild pancreatitis [p = 0.05, odds ratio (OR): 5.5, 95% confidence interval (CI): 1.04-29.0]. Twenty percent (7/35) of the patients had changes consistent with chronic pancreatitis on baseline SMRP, which persisted in all cases. Of the 29% patients with acute changes on baseline SMRP, the acute changes resolved in 50% and chronic pancreatitis was detected in the remaining 50% at 2 years. Development of chronic changes did not depend on continued alcohol consumption, as it was also found in 3 patients practising complete abstinence following their first attack of AAP. The presence of a chronic pseudocyst at 2 years predicted pancreatitis when compared to patients lacking pseudocyst formation: 4 (80%) versus 5 (17%) (p = 0.01, OR: 20.0, 95% CI: 1.83-219).The severity of the first episode of AAP was associated with deteriorated diabetes control, but not with pancreatic exocrine dysfunction at 2 years. The number of patients with chronic changes on SMRP increased independently of alcohol consumption. Chronic pseudocyst formation seen on SMRP 2 years after AAP was significantly associated with recurrence of pancreatitis. |
| Databáze: | OpenAIRE |
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