Identification of Surface IgM as the Target Antigen of Cold Lymphocytotoxins*
| Autor: | Paul I. Terasaki, Hihashi Takahashi, Yuichi Iwaki, Seizoh Nakata |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Immunology
Receptors Antigen B-Cell Heterologous Biology Biochemistry SURFACE IG Genetics Animals Humans Immunology and Allergy Cytotoxic T cell Antigens Surface IgM Cytotoxicity Antilymphocyte Serum Target antigen Antiserum B-Lymphocytes General Medicine Molecular biology Antibodies Anti-Idiotypic Cold Temperature Immunoglobulin M biology.protein Rabbits Antibody |
| Zdroj: | Tissue Antigens. 16:176-180 |
| ISSN: | 1399-0039 0001-2815 |
| Popis: | IgG and IgM were stripped from the surface of human B lymphocytes using heterologous anti-IgG or IgM antisera. The percent SIg (surface Ig) determined by fluorescence for SIgM was reduced from 55% to 20%, or a reduction of 64%. Upon stripping SIgM, the B lymphocytes were no longer killed by seven different cold cytotoxic antibodies obtained from kidney transplant patients. We conclude that SIgM is the target of cold cytotoxins. These cold cytotoxic antibodies are postulated to be immunoregulatory antibodies. They are less specific than anti-idiotypic antibodies. |
| Databáze: | OpenAIRE |
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