Human papillomavirus DNA and p16 expression in head and neck squamous cell carcinoma in young French patients
| Autor: | Christiane Mougin, Alexis Overs, Marie-Paule Algros, Christine Soret, David Guenat, Jean-Luc Prétet, Olivier Mauvais, Virginie L'Huillier, Chloé Molimard |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
virus DNA
Medicine (General) Alphapapillomavirus Biochemistry 03 medical and health sciences 0302 clinical medicine R5-920 Human papillomavirus DNA Medicine Humans 030212 general & internal medicine Human papillomavirus Risk factor human papillomavirus Papillomaviridae young patient Cyclin-Dependent Kinase Inhibitor p16 Retrospective Studies business.industry Squamous Cell Carcinoma of Head and Neck Biochemistry (medical) Papillomavirus Infections Head and neck squamous cell carcinoma Cell Biology General Medicine Middle Aged medicine.disease Head and neck squamous-cell carcinoma Hpv testing Head and Neck Neoplasms 030220 oncology & carcinogenesis p16 expression DNA Viral Cancer research Carcinoma Squamous Cell Biomarker (medicine) biomarker business Retrospective Clinical Research Report |
| Zdroj: | Journal of International Medical Research, Vol 49 (2021) The Journal of International Medical Research |
| ISSN: | 1473-2300 |
| Popis: | Objectives Human papillomavirus (HPV) is a risk factor for head and neck squamous cell carcinoma (HNSCC), which is currently increasing worldwide. We evaluated the prevalence of HPV DNA and p16 expression in HNSCC patients age Methods Thirty-nine patients aged Results The overall prevalence of HPV infection was 11.7%. HPV16 was the only genotype detected in 4/39 and 5/38 patients, and p16 was expressed in 6/39 and 4/38 patients aged Conclusions HPV-positivity and p16 expression were similar in both age groups. The results suggest that p16 immunohistochemistry may provide a prognosis biomarker for all HNSCCs, not only oropharyngeal cancers, and this should be addressed in large clinical trials. |
| Databáze: | OpenAIRE |
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