Clinico-pathological significance of Drp1 dysregulation and its correlation to apoptosis in oral cancer patients
Autor: | Kabita Chatterjee, Ananya Barui, Amit Roy Chowdhury, Aritri Ghosh |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Dynamins Apoptosis Mitochondrial Dynamics 03 medical and health sciences 0302 clinical medicine medicine Humans Cyclin D1 Molecular Biology business.industry Cancer Cell Biology Cell cycle medicine.disease Mitochondria Up-Regulation Gene Expression Regulation Neoplastic 030104 developmental biology Proto-Oncogene Proteins c-bcl-2 Case-Control Studies Cancer management Cancer cell Cancer research Carcinoma Squamous Cell Molecular Medicine Biomarker (medicine) Clinico pathological Mitochondrial fission Mouth Neoplasms business Reactive Oxygen Species 030217 neurology & neurosurgery |
Zdroj: | Mitochondrion. 52 |
ISSN: | 1872-8278 |
Popis: | Dysregulation in mitochondrial dynamics has been associated with several diseases including cancer. Present study assessed the alteration in mitochondrial fission protein (Drp1) in oral epithelial cells collected from clinically confirmed pre-cancer and cancer patients and further correlates it with the cellular apoptosis signaling. Results indicate the ROS accumulation in OSCC patients is accompanied by several changes including increase in mitochondrial mass, expression of mitochondrial fission protein (Drp1) and alteration in apoptotic signaling. The positive co-relation has been observed between the expressions of anti-apoptotic Bcl-2proteinswith mitochondrial fission protein Drp1. Higher mitochondrial fission in oral cancer cells was also correlated with the increased expression of cell cycle marker CyclinD1 indicating highly proliferative stage of oral cancer cells. The clinical correlation can be extended to develop biomarker for diagram and program in oral cancer management. |
Databáze: | OpenAIRE |
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