Subcutaneous tranexamic acid in upper eyelid blepharoplasty: a prospective randomized pilot study
| Autor: | Elkanah Rosenfeld, Oded Sagiv, Uriel Martinowitz, Tamar Brutman Barazani, Elinor Kalderon, Isaac Zilinsky, Guy J. Ben Simon, Ofira Zloto |
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| Rok vydání: | 2018 |
| Předmět: |
Blepharoplasty
Male medicine.medical_specialty Lidocaine Injections Subcutaneous medicine.medical_treatment Operative Time Ecchymosis Blood Loss Surgical Pilot Projects Postoperative Hemorrhage 030230 surgery Placebo 03 medical and health sciences 0302 clinical medicine Double-Blind Method 030202 anesthesiology medicine Humans Prospective Studies Prospective cohort study Aged Aged 80 and over business.industry Eyelids General Medicine Middle Aged Antifibrinolytic Agents Surgery Ophthalmology Treatment Outcome medicine.anatomical_structure Tranexamic Acid Hemostasis Chalazion Female Eyelid medicine.symptom business Tranexamic acid medicine.drug |
| Zdroj: | Canadian Journal of Ophthalmology. 53:600-604 |
| ISSN: | 0008-4182 |
| DOI: | 10.1016/j.jcjo.2018.01.006 |
| Popis: | Objective Postoperative ecchymoses or hematomas can prolong healing from surgery, and a search for locally administered agents that decrease bleeding is warranted. The objective of this study is to evaluate whether preoperative subcutaneous injection of tranexamic acid (TXA) reduces intra- and postoperative bleeding or ecchymoses in skin-only upper eyelid blepharoplasty surgery. Design This is a prospective randomized, double-blind, controlled study. Participants We included 34 consecutive patients who were referred to an upper eyelid blepharoplasty surgery in our institution. Methods The patients were equally randomized to a preoperative local injection of lidocaine mixed with either TXA or normal saline. All patients stopped antiaggregates 1 week before surgery. All surgeries were performed by a single surgeon who was unaware of group assignment. Total surgical time, cumulative time of cautery use, blood loss, the surgeon’s assessment of bleeding extent, pain level reported by the patient, periocular ecchymoses during the first postoperative week, and time for patient’s return to normal daily activity were recorded. Results There was a trend toward smaller ecchymoses in the TXA group compared with the placebo group on the seventh day (p = 0.072). There were no group differences in total surgery time, cumulative cautery time, net blood weight in surgical pads, patient-reported pain level, surgeon’s assessment of hemostasis, or periocular ecchymosis size on the first postoperative day. Conclusions Subcutaneous TXA was associated with similar intra- and postoperative hemorrhage in upper eyelid blepharoplasty compared with placebo. The effect of TXA in patients who did not stop antiaggregate use before surgery warrants further study. |
| Databáze: | OpenAIRE |
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