Effects of dextran sulphate on lymphoblast extravasation into inflammatory skin sites
| Autor: | Alfredo Salerno, Pietro Di Fiore, A. Bellavia, Vincenzo Marino, Salvatore M. Peri, Ignazio Brusca |
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| Rok vydání: | 1987 |
| Předmět: |
Male
Cellular immunity Erythrocytes Dermatitis Mice Inbred Strains Inflammation Oxazolone Mice chemistry.chemical_compound Cell Movement In vivo medicine Animals Hypersensitivity Delayed Lymphocytes Pharmacology business.industry Lymphoblast Dextran Sulfate Immunization Passive Dextrans Molecular biology Extravasation In vitro chemistry Delayed hypersensitivity Immunology Female medicine.symptom business |
| Zdroj: | Immunopharmacology. 13:173-180 |
| ISSN: | 0162-3109 |
| DOI: | 10.1016/0162-3109(87)90055-5 |
| Popis: | The effects of high molecular weight dextran sulphate (DXS) on the migration of 125I-labelled deoxyuridine-labelled peripheral lymphoblasts (stimulated by oxazolone) were studied in vivo by injecting the drug (50 mg/kg) subcutaneously in recipients, and by following the fate of oxazolone-stimulated peripheral lymphocytes treated in vitro with DXS in non-treated syngeneic recipients. Both types of experiments demonstrate that DXS considerably reduces lymphoblast extravasation in skin sites inflamed either by non-immune causes or by DTH. Our results also demonstrate that oxazolone-stimulated peripheral lymphocytes, after in vitro treatment with DXS, are unable to transfer antigen-specific contact hypersensitivity to unsensitized recipients. The results obtained suggest that the drug acts on both T effector cells and lymphoblasts. |
| Databáze: | OpenAIRE |
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