Indomethacin as a diagnostic and therapeutic tool in the management of progressive cervical shortening diagnosed by trans-vaginal sonography
| Autor: | Alexander D. Kofinas, Jason Kofinas |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Birth weight Indomethacin Bed rest Obstetric Labor Premature Nifedipine Pregnancy medicine Humans Cervical cerclage Cervix Cerclage Cervical Retrospective Studies business.industry Obstetrics and Gynecology medicine.disease Surgery Cervical Length Measurement medicine.anatomical_structure Tocolytic Agents Pediatrics Perinatology and Child Health Gestation Female Uterine Cervical Incompetence business medicine.drug |
| Zdroj: | The journal of maternal-fetalneonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 24(1) |
| ISSN: | 1476-4954 |
| Popis: | To evaluate the role of indomethacin in discriminating between preterm labour and cervical insufficiency-related cervical shortening.Retrospective analysis of all cases of cervical shortening on singleton gestations. All patients were treated according to our protocol with one or more of the following three modalities: (1) bed rest only, (2) bed rest and indomethacin and (3) cervical cerclage, bed rest, and indomethacin.foetal loss24 weeks, birth weight, delivery34 weeks, and delivery37 weeks.We treated 342 patients: 167 (48.8%) with bed rest only, 21 (6.1%) with cerclage, and 154 (45.1%) with indomethacin. By 28 weeks 56 (16.3%) remained stable or improved with bed rest only, 91 (26.6%) failed indomethacin and required cerclage, and the remaining 173 (50.6%) responded well to indomethacin and nifedipine. Birth weight was 3119 g ± 651 (SD) and GA at delivery 37.4 weeks ± 2.5 (SD). Of the 342 patients, 4 (1.2%) aborted24 weeks, 1 was terminated (achondroplasia), 320 (93.6%) patients delivered34 weeks and 301 (88.1%)37 weeks.Use of indomethacin in patients with cervical shortening discriminates patients with cervical insufficiency from those in premature labour and improves outcomes in comparison to existing published reports. |
| Databáze: | OpenAIRE |
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