Is Acute Myeloblastic Leukemia in Children Under 2 Years of Age a Specific Entity? A Report from the FRENCH ELAM02 Study Group
Autor: | Brigitte Nelken, O Fenneteau, Elodie Gouache, Yves Bertrand, Arnaud Petit, Guy Leverger, S Blais, H Boutroux, Wendy Cuccuini, Stéphane Ducassou, Thierry Leblanc, Marceau-A Renaut, M Pasquet, Hélène Lapillonne, André Baruchel, G. Michel, Virginie Gandemer |
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Rok vydání: | 2019 |
Předmět: |
Pediatrics
medicine.medical_specialty education.field_of_study biology Acute myeloblastic leukemia lcsh:RC633-647.5 business.industry Incidence (epidemiology) Population Myeloid leukemia lcsh:Diseases of the blood and blood-forming organs Hematology medicine.disease Article KMT2A Cohort biology.protein Overall survival Medicine business Skin lesion education |
Zdroj: | HemaSphere HemaSphere, Vol 3, Iss 6, p e316 (2019) |
ISSN: | 2572-9241 |
Popis: | The clinical and biological characteristics of children under 2 years (infants) with acute myeloid leukemia (AML) are different from those of older children. We aimed to describe the specific characteristics of this population and the potential factors that influence the prognosis. We analyzed data concerning 438 children with newly-diagnosed AML treated in the ELAM02 protocol between March 2005 and December 2011, of which 103 were under 2 years old at diagnosis. The evaluation criteria were overall survival (OS) and event-free survival (EFS) of infants vs older children. The clinical and biological features were secondary criteria. Infants presented more frequent extra-medullary presentation than older children. They had a significantly higher proportion of skin lesions and central nervous system involvement (15% vs 3%, p |
Databáze: | OpenAIRE |
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