The Incubation of 13α,17-Dihydroxystemodane with Cephalosporium aphidicola
| Autor: | Ricardo Guillermo, Juan A. Garbarino, María C. Chamy, Melchor G. Hernández, Braulio M. Fraga |
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| Přispěvatelé: | Ministerio de Ciencia e Innovación (España) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Aphidicolin
Cephalosporium aphidicola biotransformations diterpenes stemodane Spectrometry Mass Electrospray Ionization Magnetic Resonance Spectroscopy Stereochemistry Pharmaceutical Science Fungus Biology Article Analytical Chemistry lcsh:QD241-441 Hydroxylation chemistry.chemical_compound lcsh:Organic chemistry Biotransformation Drug Discovery Physical and Theoretical Chemistry Incubation Organic Chemistry Substrate (chemistry) biology.organism_classification Acremonium Transformation (genetics) chemistry Chemistry (miscellaneous) Molecular Medicine Xenobiotic |
| Zdroj: | Molecules Molecules; Volume 17; Issue 2; Pages: 1744-1750 Digital.CSIC. Repositorio Institucional del CSIC instname Molecules, Vol 17, Iss 2, Pp 1744-1750 (2012) |
| ISSN: | 1420-3049 |
| Popis: | The biotransformation of 13a,17-dihydroxystemodane (3) with the fungus Cephalosporium aphidicola afforded 13a,17,18-trihydroxystemodane (4), 3b,13a,17-tri-hydroxystemodane (5), 13a,17-dihydroxy-stemodan-18-oic acid (6), 3b,11β,13a,17-tetra-hydroxystemodane (7), 11β,13a,17,18-tetrahydroxystemodane (8) and 3b,13a,17,18-tetra-hydroxystemodane (9). The hydroxylation at C-18 of the substrate points to a biosynthetically-directed transformation, because aphidicolin (2) is hydroxylated at this carbon. However, the C-3(b) and C-11(b) hydroxylations seem to indicate a xenobiotic biotransformation. This work has been supported by grant CTQ2009-14629-C02-01, Ministerio de Ciencia e Innovación (MICINN), Spain. |
| Databáze: | OpenAIRE |
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