Nrf3-deficient mice are not protected against acute lung and adipose tissue damages induced by butylated hydroxytoluene
| Autor: | Volker Blank, Derjuga Anna, Zaynab Nouhi, Marilène Paquet, Grégory Chevillard |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
BHT
medicine.medical_specialty Pparg NF-E2-Related Factor 2 Adipose Tissue White NF-E2-Related Factor 1 Biophysics Adipose tissue White adipose tissue Biology Nrf3 Biochemistry CCAAT-Enhancer-Binding Protein-beta Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Structural Biology Internal medicine Acute lung injury Genetics medicine CEBPB Animals Butylated hydroxytoluene NRF1 Lung Molecular Biology 030304 developmental biology 0303 health sciences Adipogenesis Wild type Cell Biology Butylated Hydroxytoluene Catalase Mice Mutant Strains Basic-Leucine Zipper Transcription Factors Endocrinology chemistry 030220 oncology & carcinogenesis |
| Zdroj: | FEBS Letters. 584:923-928 |
| ISSN: | 0014-5793 |
| Popis: | We found that both wild type and Nrf3 (NF-E2-related factor 3) deficient mice are sensitive to BHT single administration exhibiting respiratory distress and considerably lose body weight following treatment. At time of sacrifice, the BHT-treated Nrf3−/− mice had lost significantly more body weight than their WT counterparts. In the lung, transcript levels of the transcription factors Nrf1, Nrf2 and Nrf3 were differentially regulated by BHT treatment. In addition, genes implicated in adipogenesis were repressed following BHT exposure in the white adipose tissue. Together, our data provide the first evidence that BHT exposure not only affects lung function but also leads to impaired adipogenesis in adipocytes. |
| Databáze: | OpenAIRE |
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