Antiviral Immune Response and the Route of Infection in Drosophila melanogaster
| Autor: | Maria-Carla Saleh, Juan A Mondotte |
|---|---|
| Přispěvatelé: | Virus et Interférence ARN - Viruses and RNA Interference, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), This work was supported by the European Research Council (FP7/2013-2019 ERC CoG 615220) and the French Government's Investissement d’Avenir program, Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases (Grant ANR-10-LABX-62-IBEID) to M.C.S. J.A.M. was supported by AXA Research fund., We apologize to all of our colleagues whose work has not been cited due to space constraints. We thank Vanesa Mongelli and Elizabeth Jaworski for fruitful discussions and help with editing. Chloé Baron for artwork, ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), European Project: 615220,EC:FP7:ERC,ERC-2013-CoG,RNAIMMUNITY(2015), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
MESH: Signal Transduction MESH: Drosophila Proteins 030106 microbiology ved/biology.organism_classification_rank.species MESH: RNA Interference Biology Antiviral immunity [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity Virus MESH: Drosophila melanogaster 03 medical and health sciences Immune system Modes of infection MESH: Dicistroviridae MESH: Animals [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Model organism Pathogen Viral tropism Innate immune system ved/biology Insect control fungi MESH: Host-Pathogen Interactions Antiviral responses biology.organism_classification Virology 3. Good health Insects 030104 developmental biology Drosophila melanogaster Drosophila C virus [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Tissue tropism [SDV.IMM]Life Sciences [q-bio]/Immunology Host–viral interactions MESH: Immunity Innate MESH: Disease Models Animal MESH: Viral Tropism |
| Zdroj: | Advances in virus research Advances in virus research, 100, pp.247-278, 2018, ⟨10.1016/bs.aivir.2017.10.006⟩ |
| Popis: | International audience; The use of Drosophila as a model organism has made an important contribution to our understanding of the function and regulation of innate immunity in insects. Indeed, insects can discriminate between different types of pathogens and mount specific and effective responses. Strikingly, the same pathogen can trigger a different immune response in the same organism, depending solely on the route of infection by which the pathogen is delivered. In this review, we recapitulate what is known about antiviral responses in Drosophila, and how they are triggered depending on the route and the mode used for the virus to infect its host. |
| Databáze: | OpenAIRE |
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