Neuroprotective effects of a combination of dexmedetomidine and hypothermia after incomplete cerebral ischemia in rats
| Autor: | Yoko Masaki, Toshiaki Nishikawa, Yoshitsugu Tobe, K. Sato, Tetsu Kimura |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Mean arterial pressure Consciousness Cell Survival medicine.medical_treatment Ischemia Pain Walking Neuroprotection Brain Ischemia Fentanyl Rats Sprague-Dawley Brain ischemia Hypothermia Induced medicine Animals Hypnotics and Sedatives Dexmedetomidine Postural Balance Saline business.industry Brain General Medicine Carbon Dioxide Hypothermia medicine.disease Combined Modality Therapy Rats Neuroprotective Agents Anesthesiology and Pain Medicine Cerebrovascular Circulation Muscle Tonus Anesthesia Nervous System Diseases medicine.symptom business medicine.drug |
| Zdroj: | Acta Anaesthesiologica Scandinavica. 54:377-382 |
| ISSN: | 1399-6576 0001-5172 |
| Popis: | BACKGROUND Dexmedetomidine and hypothermia are known to reduce neuronal injury following cerebral ischemia. We examined whether a combination of dexmedetomidine and hypothermia reduces brain injury after transient forebrain ischemia in rats to a greater extent than either treatment alone. METHODS Thirty-eight male Sprague-Dawley rats were anesthetized with fentanyl and nitrous oxide in oxygen. Four groups were tested: group C (saline 1 ml/kg, temporal muscle temperature 37.5 degrees C); group H (saline 1 ml/kg, 35.0 degrees C); group D (dexmedetomidine 100 microg/kg, 37.5 degrees C); and group DH (dexmedetomidine 100 microg/kg, 35.0 degrees C). Dexmedetomidine or saline was administered intraperitoneally 30 min before ischemia. Cerebral ischemia was produced by right carotid artery ligation with hemorrhagic hypotension (mean arterial pressure 40 mmHg) for 20 min. Neurologic outcome was evaluated at 24, 48, and 72 h after ischemia. Histopathology was evaluated in the caudate and hippocampus at 72 h after ischemia. RESULTS Neurologic outcome was significantly better in the group DH than the group C (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|