Sperm motion parameters after suppression of spermatogenesis with a gonadotropin-releasing hormone antagonist plus testosterone supplementation
| Autor: | Spyros N. Pavlou, M.C. Bastias, H. Kamijo |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Azoospermia
endocrine system medicine.medical_specialty medicine.diagnostic_test urogenital system medicine.drug_class Obstetrics and Gynecology Semen General Medicine Semen analysis Biology Hormone antagonist medicine.disease Sperm Gonadotropin-releasing hormone antagonist Andrology Endocrinology Reproductive Medicine Internal medicine medicine Spermatogenesis Sperm motility |
| Zdroj: | Fertility and Sterility. 59:1261-1265 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(16)55987-1 |
| Popis: | Objective To evaluate whether the chronic administration of a GnRH antagonist supplemented with T enanthate affects sperm motion parameters. Design Prospective study. Setting Academic medical research environment. Patients/Participants Six normospermic men of reproductive age. Intervention A 20-week treatment included the administration of 10mg of GnRH antagonist every day and 25mg of T enanthate once a week. Main Outcome Measure Computerized sperm motion analysis on each participant every 2weeks for a period of 11months. Results Sperm concentration decreased after 4weeks of the GnRH antagonist administration, accompanied by a reduction of sperm motility from an initial mean value of 56% to 34% on treatment week 4 and 21% on treatment week 6. In contrast, sperm velocity, linearity, amplitude of the lateral head displacement, and beat cross-frequency values did not significantly change in spite of reduced overall sperm concentration and motility. Azoospermia was reached within 6 to 12weeks of the GnRH administration, and it was sustained during the treatment period. During recovery of spermatogenesis, sperm movement parameters returned to initial values earlier than sperm concentration and normal morphology. All participants recovered initial semen parameters 20weeks after the end of treatment. Conclusion The administration of a GnRH antagonist supplemented with T enanthate successfully induced reversible suppression of spermatogenesis. The sperm motion characteristics appeared to be the last parameters to decline and the first to return to initial values after the treatment. |
| Databáze: | OpenAIRE |
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