Bovine placental lactogen is a potent stimulator of growth and displays strong binding to hepatic receptor sites of coho salmon
| Autor: | Ernest G. Jaworski, Edward M. Donaldson, Robert H. Devlin, Gwen G. Krivi, John C. Byatt, Timothy Y. Yesaki, W.Craig Clarke, Ewen McLean |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Receptors Peptide Endocrinology Internal medicine medicine Animals Bovine somatotropin Placental lactogen Bovine serum albumin Receptor Salmonidae Strong binding biology Dose-Response Relationship Drug Single injection Oncorhynchus kisutch biology.organism_classification Placental Lactogen Prolactin Liver Growth Hormone biology.protein Microsomes Liver Animal Science and Zoology Cattle |
| Zdroj: | General and comparative endocrinology. 95(1) |
| ISSN: | 0016-6480 |
| Popis: | Juvenile coho salmon were treated with bovine placental lactogen (bPL) and bovine growth hormone (bGH) to examine the growth promoting activities of these proteins in a lower vertebrate. Fish were intraperitoneally injected either with 0.5 or 5.0 micrograms/g bPL or with 5.0 micrograms/g bGH once a week for 5 weeks. After only a single injection and 1 week of growth, the high dose of bPL stimulated a significant increase in weight and length relative to untreated fish or fish treated with a control protein, bovine serum albumin. At the end of the experiment, all hormone-treated groups were significantly larger than controls. Fish treated with 5 micrograms/g bPL gained more than three times as much weight as controls. The 5.0 micrograms/g bGH group grew at the same rate as fish treated with one-tenth this dose of bPL, indicating that bPL is a potent stimulator of growth in this species. Radioreceptor assays performed on coho salmon liver membrane preparations indicate that bPL binds with approximately 430-fold higher affinity than bGH, and some 8000-fold higher affinity than bovine prolactin. The action of bPL relative to the structure and function of salmonid pituitary hormones is discussed. |
| Databáze: | OpenAIRE |
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