Effective immune restoration after immunosuppressant discontinuation in a lupus patient presenting progressive multifocal leukoencephalopathy
| Autor: | Sandrine Morell-Dubois, H. Charlanne, Viviane Queyrel, Claude-Alain Maurage, Eric Hachulla, Pierre-Yves Hatron, Patrick Vermersch, David Launay, Arnaud Lacour, Charles Laurent, Hélène Maillard, Marc Lambert, Guillaume Lefèvre |
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| Rok vydání: | 2009 |
| Předmět: |
Opportunistic infection
viruses JC virus medicine.disease_cause Immunocompromised Host Immune reconstitution inflammatory syndrome Adrenal Cortex Hormones Immune Reconstitution Inflammatory Syndrome Immunopathology medicine Humans Lupus Erythematosus Systemic Systemic lupus erythematosus Slow virus business.industry Progressive multifocal leukoencephalopathy Leukoencephalopathy Progressive Multifocal Brain Recovery of Function Middle Aged Mycophenolic Acid medicine.disease JC Virus Discontinuation Withholding Treatment Neurology Immune System Immunology Female Neurology (clinical) business Immunosuppressive Agents |
| Zdroj: | Journal of the Neurological Sciences. 287:246-249 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/j.jns.2009.09.014 |
| Popis: | Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection of the central nervous system with JC virus. Few cases have been described in lupus patients. We describe biopsy-proven PML in a lupus patient receiving mycophenolate mofetil and corticosteroids. Although the patient received no antiviral treatment, the polymerase chain reaction test for JC virus became negative in cerebrospinal fluid after immunosuppressant discontinuation and the patient survived. We discuss the restoration of immune efficiency after immunosuppressant discontinuation in this case and compare the clinical, radiological and histological features with the inflammatory PML form described in human immunodeficiency virus-infected patients. |
| Databáze: | OpenAIRE |
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