Immune regulatory mechanisms in ANCA-associated vasculitides

Autor: Peter Heeringa, Wayel H. Abdulahad, Cees G. M. Kallenberg, Nikola Lepse
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Pathology
medicine.medical_specialty
MICROSCOPIC POLYANGIITIS
Neutrophils
T cell
Immunology
T cells
Vasculitides
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
SYSTEMIC VASCULITIS
urologic and male genital diseases
DISEASE-ACTIVITY
T-Lymphocytes
Regulatory
Antibodies
Antineutrophil Cytoplasmic
Epitopes
Immune system
WEGENERS-GRANULOMATOSIS
immune system diseases
MEMORY T-CELLS
CYTOPLASMIC AUTOANTIBODIES
medicine
Humans
Immunology and Allergy
cardiovascular diseases
skin and connective tissue diseases
B cell
Inflammation
ACTIVATION IN-VITRO
B-Lymphocytes
Regulatory
B cells
Granuloma
business.industry
ANCA
Autoantibody
T-Lymphocytes
Helper-Inducer
T lymphocyte
medicine.disease
NATURAL AUTOANTIBODIES
respiratory tract diseases
medicine.anatomical_structure
B-CELLS
TH17 CELLS
business
Vasculitis
Microscopic polyangiitis
Signal Transduction
Systemic vasculitis
Zdroj: Autoimmunity reviews. 11(2):77-83
ISSN: 1568-9972
DOI: 10.1016/j.autrev.2011.08.002
Popis: A group of primary vasculitides is associated with the presence of anti-neutrophil cytoplasmic autoantibodies (ANCA). In these diseases, the contribution of ANCA to disease pathogenesis has been studied extensively. Also, in patients with ANCA-associated vasculitides, the T lymphocyte compartment is dysregulated, as aberrant distribution and function of T cell subsets has been shown. In this review we will discuss the putative role of T lymphocytes in inflammation and granuloma formation, as well as the involvement of B cell compartments in the pathophysiology of ANCA-associated vasculitis.
Databáze: OpenAIRE
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