Charge detection mass spectrometry for the analysis of viruses and virus-like particles
| Autor: | Lohra M. Miller, Martin F. Jarrold |
|---|---|
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Essays in Biochemistry. 67:315-323 |
| ISSN: | 1744-1358 0071-1365 |
| Popis: | Heterogeneity usually restricts conventional mass spectrometry to molecular weights less than around a megadalton. As a single-particle technique, charge detection mass spectrometry (CDMS) overcomes this limitation. In CDMS, the mass-to-charge (m/z) ratio and charge are measured simultaneously for individual ions, giving a direct mass measurement for each ion. Recent applications include the analysis of viruses, virus-like particles, vaccines, heavily glycosylated proteins, and gene therapy vectors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|